Biography:John M. Jumper

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John Jumper
Jumper giving his 2024 Nobel Prize lecture
Born
John Michael Jumper

1985 (age 40–41)
Little Rock, Arkansas, U.S.
Alma mater
Known forAlphaFold
AwardsMarshall Scholarship (2007)
Nature's 10 (2021)
BBVA Foundation Frontiers of Knowledge Award (2022)
Breakthrough Prize in Life Sciences (2023)
Nobel Prize in Chemistry (2024)
Scientific career
FieldsArtificial intelligence
Machine learning
InstitutionsGoogle
DeepMind
ThesisNew Methods Using Rigorous Machine Learning for Coarse-Grained Protein Folding and Dynamics (2017)
Doctoral advisorTobin R. Sosnick
Karl Freed

John Michael Jumper (born 1985)[1] is an American chemist and computer scientist. Jumper and Demis Hassabis were awarded the 2024 Nobel Prize in Chemistry for protein structure prediction.[2][3]

As of 2025 Jumper serves as director at Google DeepMind.[4][5][6] Jumper and his colleagues created AlphaFold,[7] an artificial intelligence (AI) model to predict protein structures from their amino acid sequence with high accuracy.[8] The AlphaFold team had released 214 million protein structures as of January 2024.[9]

The scientific journal Nature included Jumper as one of the ten "people who mattered" in science in their annual listing of Nature's 10 in 2021.[8][10]

Education

Jumper graduated from Pulaski Academy in 2003[11]. He received a Bachelor of Science with majors in physics and mathematics from Vanderbilt University in 2007,[12] a Master of Philosophy in theoretical condensed matter physics from the University of Cambridge where he was a student of St Edmund’s College, Cambridge in 2010 on a Marshall Scholarship,[13] a Master of Science in theoretical chemistry from the University of Chicago in 2012, and a Doctor of Philosophy in theoretical chemistry from the University of Chicago in 2017.[14] His doctoral advisors at the University of Chicago were Tobin R. Sosnick and Karl Freed.[15]

Career and research

Jumper's research investigates algorithms for protein structure prediction.[4]

AlphaFold

See also: AlphaFold and Protein structure prediction
This image represents the final product of AlphaFold and it compares its results with other competitors at the CASP competition.

AlphaFold[7][16] is a deep learning algorithm developed by Jumper and his team at DeepMind, a research lab acquired by Google's parent company Alphabet Inc. It is an artificial intelligence program which performs predictions of protein structure.[17]

Awards and honors

In November 2020, AlphaFold was named the winner of the 14th Critical Assessment of Structure Prediction (CASP) competition.[18][19][20] This international competition benchmarks algorithms to determine which one can best predict the 3D structure of proteins. AlphaFold won the competition, outperforming other algorithms scoring above 90 for around two-thirds of the proteins in CASP's global distance test (GDT), a test that measures the degree to which a computational program predicted structure is similar to the lab experiment determined structure, with 100 being a complete match, within the distance cutoff used for calculating GDT.[21][22]

In 2021, Jumper was awarded the BBVA Foundation Frontiers of Knowledge Award in the category "Biology and Biomedicine".[23] In 2022 Jumper received the Wiley Prize in Biomedical Sciences[24] and for 2023 the Breakthrough Prize in Life Sciences for developing AlphaFold, which accurately predicts the structure of a protein.[25] In 2023 he was awarded the Canada Gairdner International Award[26] and the Albert Lasker Award for Basic Medical Research.[27]

Jumper at the 2024 Nobel Week press conference

In 2024, Jumper and Demis Hassabis shared half of the Nobel Prize in Chemistry for their protein folding predictions, the other half went to David Baker for computational protein design.[2][3]

In 2025, Jumper received the Golden Plate Award of the American Academy of Achievement and the Marshall Medal of the Marshall Aid Commemoration Commission.[28][29] He was elected a Fellow of the Royal Society (FRS) that same year.[30] In 2026, he was elected a member of the National Academy of Engineering.[31]

References

  1. ↑ "John M. Jumper: Facts". Nobel Prize Outreach AB. 2024. https://www.nobelprize.org/prizes/chemistry/2024/jumper/facts. 
  2. ↑ 2.0 2.1 "The Nobel Prize in Chemistry 2024". Nobel Media AB. https://www.nobelprize.org/prizes/chemistry/2024/summary/. Retrieved October 9, 2024. 
  3. ↑ 3.0 3.1 "Press release: The Nobel Prize in Chemistry 2024" (in en-US). https://www.nobelprize.org/prizes/chemistry/2024/press-release/. 
  4. ↑ 4.0 4.1 John Jumper publications indexed by Google Scholar
  5. ↑ John Jumper publications from Europe PubMed Central
  6. ↑ Eisenstein, Michael (2021). "Artificial intelligence powers protein-folding predictions". Nature (Springer Nature) 599 (7886): 706–708. doi:10.1038/d41586-021-03499-y. https://www.nature.com/articles/d41586-021-03499-y. Retrieved December 24, 2021. 
  7. ↑ 7.0 7.1  , Wikidata Q107555821
  8. ↑ 8.0 8.1 Maxmen, Amy (2021). "Nature's 10: John Jumper: Protein predictor". Nature (Springer Nature) 600 (7890): 591–604. doi:10.1038/d41586-021-03621-0. PMID 34912110. 
  9. ↑ Varadi, Mihaly; Bertoni, Damian; Magana, Paulyna; Paramval, Urmila; Pidruchna, Ivanna; Radhakrishnan, Malarvizhi; Tsenkov, Maxim; Nair, Sreenath et al. (2024-01-05). "AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences". Nucleic Acids Research 52 (D1): D368–D375. doi:10.1093/nar/gkad1011. ISSN 1362-4962. PMID 37933859. PMC 10767828. https://pubmed.ncbi.nlm.nih.gov/37933859. 
  10. ↑ John Jumper on LinkedIn
  11. ↑ https://blog.pulaskiacademy.org/pa-alum-john-jumper-wins-nobel
  12. ↑ Doster, Stephen (August 8, 2023). "John Jumper, developer of AlphaFold, to present an Apex Lecture on August 30" (in en-US). https://medschool.vanderbilt.edu/basic-sciences/2023/08/08/john-jumper-developer-of-alphafold-to-present-an-apex-lecture-on-august-30/. 
  13. ↑ "University of Cambridge alumni awarded 2024 Nobel Prize in Chemistry | University of Cambridge" (in en). October 9, 2024. https://www.cam.ac.uk/research/news/university-of-cambridge-alumni-awarded-2024-nobel-prize-in-chemistry. 
  14. ↑ "UChicago alum John Jumper shares Nobel Prize for model to predict protein structures | University of Chicago News" (in en). October 9, 2024. https://news.uchicago.edu/story/uchicago-alum-john-jumper-shares-nobel-prize-model-predicting-protein-structures. 
  15. ↑ Jumper, John Michael (2017). New methods using rigorous machine learning for coarse-grained protein folding and dynamics. chicago.edu (PhD thesis). University of Chicago. doi:10.6082/M1BZ647N. OCLC 1237239279. ProQuest 1883866286.
  16. ↑  , Wikidata Q92669549
  17. ↑ "AlphaFold". https://deepmind.com/research/case-studies/alphafold. 
  18. ↑ "AlphaFold: a solution to a 50-year-old grand challenge in biology". November 30, 2020. https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology. 
  19. ↑ Sample, Ian (December 2, 2018). "Google's DeepMind predicts 3D shapes of proteins". The Guardian. https://www.theguardian.com/science/2018/dec/02/google-deepminds-ai-program-alphafold-predicts-3d-shapes-of-proteins. 
  20. ↑ Shead, Sam (November 30, 2020). "DeepMind solves 50-year-old 'grand challenge' with protein folding A.I." (in en). https://www.cnbc.com/2020/11/30/deepmind-solves-protein-folding-grand-challenge-with-alphafold-ai.html. 
  21. ↑ "DeepMind's protein-folding AI has solved a 50-year-old grand challenge of biology" (in en). https://www.technologyreview.com/2020/11/30/1012712/deepmind-protein-folding-ai-solved-biology-science-drugs-disease/. 
  22. ↑ Robert F. Service, 'The game has changed.' AI triumphs at solving protein structures, Science, November 30, 2020
  23. ↑ "BBVA Foundation Frontiers of Knowledge Award 2022". https://www.frontiersofknowledgeawards-fbbva.es. 
  24. ↑ "Wiley Prize 2022". https://www.wiley.com//WileyCDA/Section/id-390059.html. 
  25. ↑ "Breakthrough Prizes 2023". https://breakthroughprize.org/News/73. 
  26. ↑ Foundation, The Gairdner (March 30, 2023). "2023 Canada Gairdner Award Winners Announced" (in en). https://www.gairdner.org/resource-hub/2023-canada-gairdner-award-winners-announced. 
  27. ↑ Admin, Lasker. "AlphaFold—for predicting protein structures" (in en-US). https://laskerfoundation.org/winners/alphafold-a-technology-for-predicting-protein-structures/. 
  28. ↑ "Golden Plate Awardees of the American Academy of Achievement". American Academy of Achievement. https://achievement.org/our-history/golden-plate-awards/#science-exploration. 
  29. ↑ "2025 Marshall Medal Recipient Dr. John Jumper" (in en-US). https://www.https://www.marshallscholarship.org/2025-marshall-medal-recipient-dr-john-jumper/. 
  30. ↑ "Exceptional scientists elected as Fellows of the Royal Society" (in en). 2025-05-20. https://royalsociety.org/news/2025/05/new-fellows/. 
  31. ↑ "National Academy of Engineering Elects 130 Members and 28 International Members" (Press release). National Academy of Engineering. February 10, 2026.

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