Biography:Tomas Lindahl

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Tomas Lindahl

FRS FMedSci
Lindahl in 2015
Born
Tomas Robert Lindahl

(1938-01-28) 28 January 1938 (age 88)[1]
Stockholm, Sweden
NationalitySwedish, naturalised British
(dual nationality)
Education
  • Karolinska Institutet (PhD)
Known forClarification of cellular resistance to carcinogens
Awards
Scientific career
Fields
Institutions
ThesisOn the structure and stability of nucleic acids in solution (1967)
Websitecrick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/

Tomas Robert Lindahl (born 28 January 1938) is a Swedish-British scientist specialising in cancer research.[7] In 2015, he was awarded the Nobel Prize in Chemistry[8] jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.[9][10][11]

Education

Lindahl was born in Kungsholmen, Stockholm, Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg.[12] He received a PhD degree in 1967,[13] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.[1]

Career and research

After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University and Rockefeller University.[14] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.[14] From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[15] He continued to research there until 2009. He has contributed to many papers on DNA repair and the genetics of cancer.[16][17][18][19][20][21][22][23][24]

Awards and honours

Lindahl was elected an EMBO Member in 1974[2] and Fellow of the Royal Society (FRS) in 1988,[4] his certificate of election reads:

Lindahl received the Royal Society's Royal Medal in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[25] He is a member of the Norwegian Academy of Science and Letters.[26] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. In 2018, he was elected a foreign associate of the National Academy of Sciences.

He shared the Nobel Prize in Chemistry in 2015.[9] The Swedish Academy noted that "The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[27]

References

  1. ↑ 1.0 1.1 ",". Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. https://www.ukwhoswho.com/view/article/oupww/whoswho/U24580.  (subscription or UK public library membership required)
  2. ↑ 2.0 2.1 "Tomas Lindahl EMBO profile". Heidelberg: European Molecular Biology Organization. https://people.embo.org/profile/tomas-lindahl. 
  3. ↑ 3.0 3.1 "Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F1988%2F20%27). 
  4. ↑ 4.0 4.1 Anon (1988). "Dr Tomas Lindahl FMedSci FRS". London: Royal Society. https://royalsociety.org/people/tomas-lindahl-11820/.  One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --
  5. ↑ "Dr Tomas Lindahl FRS FMedSci". London: Academy of Medical Sciences. http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/dr-tomas-lindahl/. 
  6. ↑ Lindahl, Tomas (2013). "My Journey to DNA Repair". Genomics, Proteomics & Bioinformatics 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229. PMID 23453014. 
  7. ↑ "Emeritus Scientist – Tomas Lindahl". The Crick. http://crick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/. 
  8. ↑ Tomas Lindahl – Nobel Prize in Chemistry 2015 on Vimeo
  9. ↑ 9.0 9.1 Broad, William J. (2015-10-07). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. https://www.nytimes.com/2015/10/08/science/tomas-lindahl-paul-modrich-aziz-sancarn-nobel-chemistry.html. 
  10. ↑ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life". Nobel Prize. https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2015/popular-chemistryprize2015.pdf. 
  11. ↑ Cressey, Daniel (2015). "DNA repair sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar share 2015 prize". Nature 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021. 
  12. ↑ Sweden, Indexed Birth Records, 1860–1941
  13. ↑ Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution (PhD thesis). Stockholm: Karolinska Institutet.
  14. ↑ 14.0 14.1 "Cancer Research UK Grants & Research – Tomas Lindahl". http://science.cancerresearchuk.org/research/loc/london/lifch/lindahlt/. 
  15. ↑ "4 ways that Tomas Lindahl’s Nobel Prize for Chemistry revolutionised cancer research", by Emma Smith, CRUK Science blog, 7 October 2015
  16. ↑ Gerken, T. is; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A. et al. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMID 17991826. Bibcode: 2007Sci...318.1469G. 
  17. ↑ Tomas Lindahl's publications indexed by the Scopus bibliographic database. (Subscription content?)
  18. ↑ Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature 362 (6422): 709–15. doi:10.1038/362709a0. PMID 8469282. Bibcode: 1993Natur.362..709L. 
  19. ↑ Wood, R. D. (2001). "Human DNA Repair Genes". Science 291 (5507): 1284–9. doi:10.1126/science.1056154. PMID 11181991. Bibcode: 2001Sci...291.1284W. 
  20. ↑ Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature 356 (6367): 356–8. doi:10.1038/356356a0. PMID 1549180. Bibcode: 1992Natur.356..356S. 
  21. ↑ Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature 419 (6903): 174–8. doi:10.1038/nature00908. PMID 12226667. Bibcode: 2002Natur.419..174T. 
  22. ↑ Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983. 
  23. ↑ Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533. 
  24. ↑ Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H et al. (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398. 
  25. ↑ "Royal recent winners". http://royalsociety.org/page.asp?id=1750. 
  26. ↑ "Gruppe 6: Cellebiologi og molekylærbiologi" (in no). Norwegian Academy of Science and Letters. http://www.dnva.no/c26849/artikkel/vis.html?tid=40126. 
  27. ↑ "The Nobel Prize in Chemistry 2015". nobelprize.org. https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2015/. 
  • Miss nobel-id as parameter including the Nobel Lecture 8 December 2015 The Intrinsic Fragility of DNA



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