Biology:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
| (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.92 | ||||||||
| CAS number | 67338-98-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (EC 2.4.1.92, uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, ganglioside GM2 synthase, ganglioside GM3 acetylgalactosaminyltransferase, GM2 synthase, UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase, GM2/GD2-synthase, beta-1,4N-aetylgalactosaminyltransferase, asialo-GM2 synthase, GalNAc-T, UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction:
UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide
This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.
References
- ↑ "The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 231 (2): 385–93. March 1971. doi:10.1016/0005-2760(71)90151-2. PMID 5554906.
- ↑ "Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver". Proceedings of the National Academy of Sciences of the United States of America 85 (19): 7044–8. October 1988. doi:10.1073/pnas.85.19.7044. PMID 3140234. Bibcode: 1988PNAS...85.7044P.
- ↑ "beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F". The Biochemical Journal 303 ( Pt 3) (3): 957–65. November 1994. doi:10.1042/bj3030957. PMID 7980468.
- ↑ "Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver". The Journal of Biological Chemistry 268 (34): 25857–64. December 1993. doi:10.1016/S0021-9258(19)74467-6. PMID 8245020.
- ↑ "Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain". Journal of Biochemistry 101 (5): 1115–27. May 1987. doi:10.1093/oxfordjournals.jbchem.a121976. PMID 3115968.
- ↑ "Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides". Biochimica et Biophysica Acta (BBA) - General Subjects 1573 (3): 356–62. December 2002. doi:10.1016/s0304-4165(02)00403-8. PMID 12417418.
- ↑ "Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions". Proceedings of the National Academy of Sciences of the United States of America 102 (8): 2725–30. February 2005. doi:10.1073/pnas.0407785102. PMID 15710896. Bibcode: 2005PNAS..102.2725Y.
External links
- (N-acetylneuraminyl)-galactosylglucosylceramide+N-acetylgalactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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