Biology:A-1,3-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase

From HandWiki
Short description: Class of enzymes
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Identifiers
EC number2.4.1.145
CAS number86498-16-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.145, N-acetylglucosaminyltransferase IV, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTIV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R [math]\displaystyle{ \rightleftharpoons }[/math] UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References

  1. "Control of glycoprotein synthesis". The Journal of Biological Chemistry 258 (10): 6162–73. May 1983. PMID 6222042. 

External links