Biology:BCAS3

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Generic protein structure example

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[1][2] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[2]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[3] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[4] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[4]

References

  1. "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54828. 
  2. 2.0 2.1 "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. December 2002. doi:10.1002/gcc.10121. PMID 12378525. 
  3. "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. April 2006. doi:10.1073/pnas.0601989103. PMID 16617102. Bibcode2006PNAS..103.6670G. 
  4. 4.0 4.1 "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. August 2007. doi:10.1210/me.2006-0514. PMID 17505058. 

External links

Further reading