Biology:Cellobiose phosphorylase

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In enzymology, a cellobiose phosphorylase (EC is an enzyme that catalyzes the chemical reaction

cellobiose + phosphate [math]\rightleftharpoons[/math] alpha-D-glucose 1-phosphate + D-glucose

Thus, the two substrates of this enzyme are cellobiose and phosphate, whereas its two products are alpha-D-glucose 1-phosphate and D-glucose.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is cellobiose:phosphate alpha-D-glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

Structural studies[edit]

As of late 2006, two structures have been solved for this class of enzymes, with PDB accession codes 2CQS and 2CQT.


  • "Purification and specificity of cellobiose phosphorylase from Clostridium thermocellum". The Journal of Biological Chemistry 243 (11): 2899–904. June 1968. PMID 5653182. 
  • "Phosphorolysis and synthesis of cellobiose by cell extracts from Ruminococcus flavefaciens". The Journal of Biological Chemistry 234: 2819–22. November 1959. PMID 13795349. phosphorylase was the original source. Read more.