Biology:Chitin synthase
| chitin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.16 | ||||||||
| CAS number | 9030-18-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a chitin synthase (EC 2.4.1.16) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and [1,4-(N-acetyl-beta-D-glucosaminyl)]n, whereas its two products are UDP and [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase. Other names in common use include chitin-UDP N-acetylglucosaminyltransferase, chitin-uridine diphosphate acetylglucosaminyltransferase, chitin synthetase, and trans-N-acetylglucosaminosylase. This enzyme participates in aminosugars metabolism.
Production
Inhibition
Benzoylurea as well as other insecticides act as insect growth regulators by inhibiting this enzyme and thus preventing the formation of chitin.[1] They are in IRAC mode of action groups 10, 15 and 16.[2]
References
- ↑ Douris, Vassilis; Steinbach, Denise; Panteleri, Rafaela; Livadaras, Ioannis; Pickett, John Anthony; Van Leeuwen, Thomas; Nauen, Ralf; Vontas, John (2016). "2016". Proceedings of the National Academy of Sciences 113 (51): 14692–14697. doi:10.1073/pnas.1618258113. PMID 27930336.
- ↑ "The IRAC Mode of Action Classification Online". https://irac-online.org/mode-of-action/classification-online/.
- "The synthesis of chitin in cell-free extracts of Neurospora crassa". J. Biol. Chem. 228 (2): 729–42. 1957. doi:10.1016/S0021-9258(18)70655-8. PMID 13475355.
- "Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae". J. Biol. Chem. 261 (32): 15147–52. 1986. doi:10.1016/S0021-9258(18)66844-9. PMID 2945823.
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