Biology:DLST

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DLST gene.

Further reading

• "Maple syrup urine disease: domain structure, mutations and exon skipping in the dihydrolipoyl transacylase (E2) component of the branched-chain alpha-keto acid dehydrogenase complex.". Mol. Biol. Med. 8 (1): 49–63. 1991. PMID 1943690. 
• "Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis.". Hepatology 11 (6): 975–81. 1990. doi:10.1002/hep.1840110611. PMID 2365294. 
• "Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex.". J. Biochem. 101 (1): 19–27. 1987. doi:10.1093/oxfordjournals.jbchem.a121891. PMID 3571202. 
• "Inhibition of glycine oxidation by pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids in rat liver mitochondria: presence of interaction between the glycine cleavage system and alpha-keto acid dehydrogenase complexes.". Arch. Biochem. Biophys. 249 (2): 263–72. 1986. doi:10.1016/0003-9861(86)90002-0. PMID 3753002. 
• "Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.". Eur. J. Biochem. 224 (1): 179–89. 1994. doi:10.1111/j.1432-1033.1994.tb20010.x. PMID 8076640. 
• "An unspliced cDNA for human dihydrolipoamide succinyltransferase: characterization and mapping of the gene to chromosome 14q24.2-q24.3.". Biochem. Biophys. Res. Commun. 196 (2): 527–33. 1993. doi:10.1006/bbrc.1993.2282. PMID 8240324. 
• "Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.". Biochim. Biophys. Acta 1216 (3): 360–8. 1994. doi:10.1016/0167-4781(93)90002-u. PMID 8268217. 
• "Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease.". Neurosci. Lett. 199 (1): 73–7. 1996. doi:10.1016/0304-3940(95)11982-3. PMID 8584231. http://repub.eur.nl/pub/72164. 
• "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle.". Biochem. Biophys. Res. Commun. 241 (1): 151–6. 1998. doi:10.1006/bbrc.1997.7784. PMID 9405249. 
• "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components.". J. Biol. Chem. 273 (37): 24158–64. 1998. doi:10.1074/jbc.273.37.24158. PMID 9727038. 
• "Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.". Ann. Neurol. 45 (1): 48–53. 1999. doi:10.1002/1531-8249(199901)45:1<48::AID-ART9>3.0.CO;2-V. PMID 9894876. 
• "[Association between DLST gene polymorphism and Alzheimer's disease]". Zhonghua Yi Xue Za Zhi 81 (20): 1246–8. 2002. PMID 11825528. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain". EMBO J. 22 (12): 2913–23. 2003. doi:10.1093/emboj/cdg299. PMID 12805207. 
• "Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association". Neurochem. Res. 29 (3): 629–35. 2004. doi:10.1023/B:NERE.0000014833.54481.1d. PMID 15038610. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.