Biology:Deoxyuridine phosphorylase
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Short description: Class of enzymes
| deoxyuridine phosphorylase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.2.23 | ||||||||
| CAS number | 37277-77-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a deoxyuridine phosphorylase is an enzyme that catalyzes the chemical reaction
- 2'-deoxyuridine + phosphate [math]\displaystyle{ \rightleftharpoons }[/math] uracil + 2-deoxy-alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are 2'-deoxyuridine and phosphate, whereas its two products are uracil and 2-deoxy-alpha-D-ribose 1-phosphate.
No enzyme is known to be specific for this reaction, hence the EC number originally assigned to this enzyme function (EC 2.4.2.23) was deleted by the IUBMB in 2013.[1] The reaction is catalysed by EC 2.4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase.
These enzymes belong to the family of glycosyltransferases, specifically the pentosyltransferases. They participate in pyrimidine metabolism.
References
- "Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats". Neurosci. Lett. 399 (3): 181–5. 2006. doi:10.1016/j.neulet.2006.01.054. PMID 16495004.
- Yamada EW (1964). "The effect of cortisol administration on the activities of uridine and deoxyuridine phosphorylases of normal and regenerating rat liver". Can. J. Biochem. 42: 317–325.
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