Biology:Dioxotetrahydropyrimidine phosphoribosyltransferase
dioxotetrahydropyrimidine phosphoribosyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.4.2.20 | ||||||||
CAS number | 37277-75-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a dioxotetrahydropyrimidine phosphoribosyltransferase (EC 2.4.2.20) is an enzyme that catalyzes the chemical reaction
- a 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
Thus, the two substrates of this enzyme are 2,4-dioxotetrahydropyrimidine D-ribonucleotide and diphosphate, whereas its two products are 2,4-dioxotetrahydropyrimidine and 5-phospho-alpha-D-ribose 1-diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase, dioxotetrahydropyrimidine phosphoribosyl transferase, and dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase.
References
- "3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES". J. Biol. Chem. 239: 2580–6. 1964. PMID 14235538.
![]() | Original source: https://en.wikipedia.org/wiki/Dioxotetrahydropyrimidine phosphoribosyltransferase.
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