Biology:FUT7
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.[1][2][3]
Function
The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM][3]
References
- ↑ "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". The Journal of Biological Chemistry 269 (24): 16789–94. June 1994. doi:10.1016/S0021-9258(19)89461-9. PMID 8207002.
- ↑ "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes". The Journal of Biological Chemistry 269 (20): 14730–7. May 1994. doi:10.1016/S0021-9258(17)36686-3. PMID 8182079.
- ↑ 3.0 3.1 "Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2529.
Further reading
- "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". The Journal of Biological Chemistry 269 (32): 20806. August 1994. doi:10.1016/S0021-9258(17)32066-5. PMID 8051184.
- "Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands". The Journal of Biological Chemistry 271 (14): 8250–9. April 1996. doi:10.1074/jbc.271.14.8250. PMID 8626519.
- "Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow". Glycobiology 7 (3): 357–65. April 1997. doi:10.1093/glycob/7.3.357. PMID 9147044.
- "Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines". Glycobiology 8 (6): 605–13. June 1998. doi:10.1093/glycob/8.6.605. PMID 9592127.
- "Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene". The Journal of Biological Chemistry 276 (34): 31575–82. August 2001. doi:10.1074/jbc.M104165200. PMID 11404359.
- "Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures". Glycobiology 11 (5): 423–32. May 2001. doi:10.1093/glycob/11.5.423. PMID 11425803.
- "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry 277 (5): 3168–75. February 2002. doi:10.1074/jbc.M107927200. PMID 11698403.
- "The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant". Glycobiology 12 (1): 15–24. January 2002. doi:10.1093/glycob/12.1.15. PMID 11825883.
- "Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element". Blood 101 (9): 3615–21. May 2003. doi:10.1182/blood-2002-07-2301. PMID 12506041.
- "H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells". The Journal of Biological Chemistry 279 (38): 39495–504. September 2004. doi:10.1074/jbc.M407904200. PMID 15262995.
- "Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII". Biochemical and Biophysical Research Communications 324 (1): 98–107. November 2004. doi:10.1016/j.bbrc.2004.09.025. PMID 15464988.
- "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". The Journal of Biological Chemistry 280 (7): 5378–90. February 2005. doi:10.1074/jbc.M410899200. PMID 15579466.
- "N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding". The Biochemical Journal 391 (Pt 3): 491–502. November 2005. doi:10.1042/BJ20050344. PMID 15926890.
- "Binding specificity of Toll-like receptor cytoplasmic domains". European Journal of Immunology 36 (3): 742–53. March 2006. doi:10.1002/eji.200535158. PMID 16482509.
- "Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway". The FEBS Journal 274 (2): 526–38. January 2007. doi:10.1111/j.1742-4658.2006.05599.x. PMID 17229154.
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