Biology:Galactoside 2-alpha-L-fucosyltransferase

From HandWiki
Short description: Class of enzymes
galactoside 2-alpha-L-fucosyltransferase
Identifiers
EC number2.4.1.69
CAS number56093-23-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a galactoside 2-alpha-L-fucosyltransferase (EC 2.4.1.69) is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + beta-D-galactosyl-R [math]\displaystyle{ \rightleftharpoons }[/math] GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase. Other names in common use include blood group H alpha-2-fucosyltransferase, guanosine diphosphofucose-galactoside 2-L-fucosyltransferase, alpha-(1->2)-L-fucosyltransferase, alpha-2-fucosyltransferase, alpha-2-L-fucosyltransferase, blood-group substance H-dependent fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase, guanosine diphosphofucose-lactose fucosyltransferase, GDP fucose-lactose fucosyltransferase, guanosine diphospho-L-fucose-lactose fucosyltransferase, guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase, guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide, alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase, H-gene-encoded beta-galactoside alpha1->2fucosyltransferase, secretor-type beta-galactoside alpha1->2fucosyltransferase, beta-galactoside alpha1->2fucosyltransferase, and GDP-L-fucose:lactose fucosyltransferase. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

References

  • "Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen". J. Biol. Chem. 250 (8): 2956–62. 1975. PMID 804484. 
  • "Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255 (11): 5373–9. 1980. PMID 7372640. 
  • "Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland". J. Biol. Chem. 255 (11): 5364–72. 1980. PMID 6246105. 
  • Grollman AP (1966). "GDP-L-fucose:lactose fucosyltransferase from mammary gland". Methods Enzymol. 8: 351–353. doi:10.1016/0076-6879(66)08065-0.