Biology:Gamma-glutamyl-gamma-aminobutyrate hydrolase

From HandWiki
Gamma-glutamyl-gamma-aminobutyrate hydrolase
Identifiers
EC number3.5.1.94
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a gamma-glutamyl-gamma-aminobutyrate hydrolase (EC 3.5.1.94) is an enzyme that catalyzes the chemical reaction

4-(gamma-glutamylamino)butanoate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-aminobutanoate + L-glutamate

Thus, the two substrates of this enzyme are 4-(gamma-glutamylamino)butanoate and H2O, whereas its two products are 4-aminobutanoate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. Other names in common use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL. This enzyme participates in urea cycle and metabolism of amino groups.

References

  • "A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12". J. Biol. Chem. 280 (6): 4602–8. 2005. doi:10.1074/jbc.M411114200. PMID 15590624.