Biology:Gamma-glutamyl-gamma-aminobutyrate hydrolase
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Short description: Class of enzymes
| Gamma-glutamyl-gamma-aminobutyrate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.94 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Gamma-glutamyl-gamma-aminobutyrate hydrolase (EC 3.5.1.94) is an enzyme characterised from Escherichia coli that catalyzes the hydrolysis of 4-(γ-glutamylamino)butanoic acid to γ-aminobutyric acid (GABA) and L-glutamic acid:[1]
- REDIRECT Template:Chemical reaction
The reaction is part of a pathway that allows bacteria to metabolise putrescine.[2][3] In potato, the enzyme regulates the amount of GABA present in response to stress.[4]
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. Other names in use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL.[5]
References
- ↑ "A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12". J. Biol. Chem. 280 (6): 4602–8. 2005. doi:10.1074/jbc.M411114200. PMID 15590624.
- ↑ Chattopadhyay, Manas K.; Chen, Weiping; Tabor, Herbert (2013). "Escherichia coli glutathionylspermidine synthetase/Amidase: Phylogeny and effect on regulation of gene expression". FEMS Microbiology Letters 338 (2): 132–140. doi:10.1111/1574-6968.12035. PMID 23106382.
- ↑ Wannasutta, Rungnapha; Boonlue, Sophon; Riddech, Nuntavun; Mongkolthanaruk, Wiyada (2025). "Isolation and optimization of Bacillus thuringiensis BRB-3 isolated from germinated black upland rice seeds for GABA production". Heliyon 11 (3). doi:10.1016/j.heliyon.2025.e41884. PMID 39916844.
- ↑ Tiwari, Jagesh Kumar; Buckseth, Tanuja; Zinta, Rasna et al. (2020). "Transcriptome analysis of potato shoots, roots and stolons under nitrogen stress". Scientific Reports 10 (1). doi:10.1038/s41598-020-58167-4. PMID 31980689.
- ↑ Enzyme 3.5.1.94 at KEGG Pathway Database.
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