Biology:Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase
| galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.79 | ||||||||
| CAS number | 62213-46-1 | ||||||||
| Alt. names | uridine, diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, globoside synthetase, UDP-N-acetylgalactosamine:globotriaosylceramide, beta-3-N-acetylgalactosaminyltransferase, galactosylgalactosylglucosylceramide, beta-D-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide, beta1,3-N-acetylgalactosaminyltransferase, globoside synthase, galactosylgalactosylglucosylceramide, beta-D-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-, glucosylceramide beta-N-acetyl-D-galactosaminyltransferase, beta3GalNAc-T1, UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-, galactosyl-(1->4)-beta-D-glucosylceramide, 3III-beta-N-acetyl-D-galactosaminyltransferase, UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-, galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide, 3III-beta-N-acetyl-D-galactosaminyltransferase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.79) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (11)-ceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)- beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide
The 3 substrates of this enzyme are UDP-N-acetyl-D-galactosamine, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-, and (11)-ceramide, whereas its 3 products are UDP, N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-, and beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide.
Wrongly characterized previously as globotriosylceramide beta-1,6-N-acetylgalactosaminyl-transferase (EC 2.4.1.154[1]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact osyl-(1->4)-beta-D-glucosyl-(11)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.
References
- ↑ "Characterization of a glycosphingolipid beta-N-acetylgalactosaminyl-transferase activity in cultured hamster (nil) cells". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 712 (2): 234–41. August 1982. doi:10.1016/0005-2760(82)90339-3. PMID 6812637.
- "Biosynthesis of a globoside-type glycosphingolipid by a -N-acetylgalactosaminyltransferase from embryonic chicken brain". J. Biol. Chem. 248 (5): 1778–85. 1973. PMID 4632917.
- "Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney". Biochim. Biophys. Acta 337 (1): 92–106. 1974. doi:10.1016/0005-2760(74)90043-5. PMID 4433547.
- "Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen". J. Biol. Chem. 259 (9): 5637–42. 1984. PMID 6425294.
- "Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase". J. Biol. Chem. 275 (51): 40498–503. 2000. doi:10.1074/jbc.M006902200. PMID 10993897.
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