Biology:Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase
| glucosaminylgalactosylglucosylceramide beta-galactosyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.86 | ||||||||
| CAS number | 9073-46-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glucosaminylgalactosylglucosylceramide beta-galactosyltransferase (EC 2.4.1.86) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(11)-ceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide
The 3 substrates of this enzyme are UDP-galactose, N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-, and glucosyl-(11)-ceramide, whereas its 3 products are UDP, beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-, and galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl- (1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase. Other names in common use include uridine, diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide, galactosyltransferase, GalT-4, paragloboside synthase, glucosaminylgalactosylglucosylceramide 4-beta-galactosyltransferase, lactotriaosylceramide 4-beta-galactosyltransferase, UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-, glucosylceramide beta-D-galactosyltransferase, and UDP-Gal:LcOse3Cer(beta 1-4)galactosyltransferase.
References
- "Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow". J. Biol. Chem. 247 (5): 1489–95. 1972. PMID 4335001.
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