Biology:Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-b-N-acetylgalactosaminyltransferase
| Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.175 | ||||||||
| CAS number | 96189-40-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
This enzyme is involved in the biosynthesis of chondroitin sulfate.
References
- ↑ "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of Biochemistry 148 (3): 463–9. May 1985. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
- ↑ "Molecular cloning and expression of a human chondroitin synthase". The Journal of Biological Chemistry 276 (42): 38721–6. October 2001. doi:10.1074/jbc.M106871200. PMID 11514575.
- ↑ "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". The Journal of Biological Chemistry 275 (31): 24124–9. August 2000. doi:10.1074/jbc.M003385200. PMID 10818104.
- ↑ "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". The Journal of Biological Chemistry 277 (24): 21567–75. June 2002. doi:10.1074/jbc.M201719200. PMID 11943778.
External links
- Glucuronosyl-N-acetylgalactosaminyl-proteoglycan+4-beta-N-acetylgalactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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