Biology:Glucuronylgalactosylproteoglycan 4-b-N-acetylgalactosaminyltransferase
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Short description: Class of enzymes
| Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.174 | ||||||||
| CAS number | 96189-39-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.174, N-acetylgalactosaminyltransferase I, glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I, UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
This enzyme requires Mn2+.
References
- ↑ "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of Biochemistry 148 (3): 463–9. May 1985. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
- ↑ "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate". The Journal of Biological Chemistry 277 (11): 8841–6. March 2002. doi:10.1074/jbc.M111434200. PMID 11788602.
External links
- Glucuronylgalactosylproteoglycan+4-beta-N-acetylgalactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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