Biology:Glycoprotein-fucosylgalactoside a-N-acetylgalactosaminyltransferase
| glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.40 | ||||||||
| CAS number | 9067-69-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.40) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose [math]\displaystyle{ \rightleftharpoons }[/math] UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl- (1,2)]-D-galactose
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-, and (1,2)]-D-galactose.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase. Other names in common use include A-transferase, histo-blood group A glycosyltransferase, (Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase), UDP-GalNAc:Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, blood-group substance A-dependent acetylgalactosaminyltransferase, fucosylgalactose acetylgalactosaminyltransferase, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A transferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose, and 3-N-acetyl-D-galactosaminyltransferase. This enzyme participates in 3 metabolic pathways: the lactoseries and neolactoseries of glycosphingolipid biosynthesis, as well as the biosynthesis of glycan structures.
Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1LZ0, 1LZI, 1R7T, 1R7V, 1R7Y, 1R81, 1WSZ, 1WT0, 1WT1, 1WT2, 1WT3, 1XZ6, 1ZHJ, 1ZI1, 1ZI3, 1ZI4, 1ZI5, 1ZJO, and 2A8W.
References
- "An enzymic basis for blood type A in humans". Arch. Biochem. Biophys. 124 (1): 609–12. 1968. doi:10.1016/0003-9861(68)90373-1. PMID 5661629.
- "Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene". J. Biochem. (Tokyo) 107 (3): 360–8. March 1990. doi:10.1093/oxfordjournals.jbchem.a123051. PMID 2341371.
- "Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase". Carbohydr. Res. 130 (1): 251–60. 1984. doi:10.1016/0008-6215(84)85283-0. PMID 6434182.
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