Biology:Haplogroup V (mtDNA)

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Haplogroup V
Possible time of originOver 14,000 years BP [1]
Possible place of originEurope (southern)
AncestorHV0a
DescendantsV1, V2, V3, V4, V5, V6, V7, V8, V9, V10, V11, V12, V14, V15, V16, V17, V18, V22, V23, V24, V25, V26, V27, V28
Defining mutations4580[2]

Haplogroup V is a human mitochondrial DNA (mtDNA) haplogroup. The clade is believed to have originated over 14,000 years ago in Southern Europe.

Origin

Haplogroup V derives from the HV0a subclade of haplogroup HV. In 1998 it was argued that V spread over Europe from an Ice Age refuge in Iberia.[3] However more recent estimates of the date of V would place it in the Neolithic.[1]

Distribution

Haplogroup V is a relatively rare mtDNA haplogroup, occurring in around 4% of native Europeans.[4] Its highest concentration is among the Saami people of northern Fennoscandia (~59%). It has been found at a frequency of approximately 10% among the Maris of the Volga-Ural region, leading to the suggestion that this region might be the source of the V among the Saami.[5][6] Haplogroup V has been observed at higher than average levels among Cantabrian people (15%) of northern Iberia,[7] and among the adjacent Basque (10.4%).[8]

Haplogroup V is also found in parts of Northwest Africa. It is mainly concentrated among the Tuareg inhabiting the Gorom-Gorom area in Burkina Faso (21%),[9] Sahrawi in the Western Sahara (17.9%),[10] and Berbers of Matmata, Tunisia (16.3%).[11] The rare V7a subclade occurs among Algerians in Oran (1.08%) and Reguibate Sahrawi (1.85%).[12]

Ancient DNA

MtDNA haplogroup V has been reported in Neolithic remains of the Linear Pottery culture at Halberstadt, Germany c. 5000 BC[13] and Derenburg Meerenstieg, Germany c. 4910 BC.[14] Haplogroup V7 was found in representative Maykop culture samples in the excavations conducted by Alexei Rezepkin.[15] Haplogroup V has been detected in representatives Trypil'ska and Unetice culture.[16][17]

Haplogroup V has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site 14,000 years BP.[18]

Haplogroup V has also been found among Somogyvár-Vinkovci culture specimens dating from the Bronze Age from Western Hungary https://www.biorxiv.org/content/10.1101/2022.02.03.478968v1.full.pdf

Tree

This phylogenetic tree of haplogroup V subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.

  • V
    • V1
      • V1a found mostly from central to northeast Europe
        • V1a1 found in Scandinavia (including Lapland), Finland and Baltic countries
        • V1a2 found in Bronze Age Poland
      • V1b found in Germany, Poland
    • V2 found in the British Isles
      • V2a found in Ireland
        • V2a1
          • V2a1a found in Finns[19]
      • V2b found in England, Germany, Denmark, Poland, Spain
        • V2b1
      • V2c found in Norway,[20] Denmark, England, Ireland, Switzerland
    • V3 found in northwest Europe / found in Late Neolithic Hungary (Bell Beaker)
      • V3b
      • V3c found in northern, central and eastern Europe
    • V4 found in France
    • V5 found in Lapland
    • V6 found in northwest Europe
    • V7
      • V7a found mostly in Slavic countries, but also in Scandinavia, Germany and France[21]
      • V7b found in eastern Europe and France[22]
    • V8 found in North Europe
    • V9
      • V9a found in the British Isles
        • V9a1
        • V9a2 found in Ireland, England, Scotland (Shetland), Denmark
    • V10 found in the British Isles, northwest France and Sweden / found in Bell Beaker Scotland
      • V10a found in Sweden,[23] Ireland,[24] Spain[25]
      • V10b found in EBA England
    • V11 found in Italy (Calabria)[26]
    • V12 found in Germany
    • V13 found in Poland and Russia
    • V14 found in Poland and Iberia
    • V15 found in England, Norway and Armenia
    • V16 found in Britain, Germany and Denmark
    • V17 found in England / found in Late Neolithic France
    • V18 found in the Netherlands, Germany and Italy
      • V18a found in Slavic countries, Sweden, Denmark, Spain, and the Netherlands[28]
    • V19 found in the United Kingdom (including Northern Ireland), Ireland
    • V20 found in Norway
    • V21
    • V22 found in Spain (including Basques) and France (Basques)
    • V23
    • V24
    • V25 found in South Europe, Berbers of Algeria and Morocco[29]
    • V26 found in Denmark and Germany
    • V27 found in Denmark
    • V28 found in Denmark
    • V29
    • V30
    • V31
    • V32
    • V33
    • V34
    • V35
    • V36
    • V37
    • V38
    • V39
    • V40
    • V41
    • V42
    • V43
    • V44
    • V45
    • V46
    • V47
    • V48
    • V49
    • V50
    • V51
    • V52
    • V53
    • V54
    • V55
    • V56
    • V57
    • V58
    • V59
    • V60
    • V61
    • V62
    • V63
    • V64
    • V65
    • V66
    • V67
    • V68
    • V69
    • V70
    • V71
    • V72
    • V73
    • V74
    • V75
    • V76
    • V77
    • V78

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References

  1. ↑ 1.0 1.1 "A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root". The American Journal of Human Genetics 90 (4): 675–684. 2012. doi:10.1016/j.ajhg.2012.03.002. PMID 22482806. 
  2. ↑ 2.0 2.1 "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–94. Feb 2009. doi:10.1002/humu.20921. PMID 18853457. 
  3. ↑ "mtDNA Analysis Reveals a Major Late Paleolithic Population Expansion from Southwestern to Northeastern Europe". American Journal of Human Genetics 62 (5): 1137–1152. 1998. doi:10.1086/301822. PMID 9545392. 
  4. ↑ Bryan Sykes (2001). The Seven Daughters of Eve. London; New York: Bantam Press. ISBN 978-0393020182. 
  5. ↑ "A recent genetic link between Sami and the Volga-Ural region of Russia". European Journal of Human Genetics 15 (1): 115–120. 2007. doi:10.1038/sj.ejhg.5201712. PMID 16985502. 
  6. ↑ "The Western and Eastern Roots of the Saami—the Story of Genetic "Outliers" Told by Mitochondrial DNA and Y Chromosomes". American Journal of Human Genetics 74 (4): 661–682. 2004. doi:10.1086/383203. PMID 15024688. 
  7. ↑ "Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain)". Annals of Human Genetics 67 (Pt 4): 329–39. Jul 2003. doi:10.1046/j.1469-1809.2003.00045.x. PMID 12914567. http://grupos.unican.es/acanto/aep/bolpas/Ann-Hum-Genet.pdf. Retrieved 2012-08-08. 
  8. ↑ "Supplemental Data Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics 84 (6): 82–93. 2009. doi:10.1016/j.ajhg.2009.05.001. PMID 19500773. 
  9. ↑ Luísa Pereira; Viktor Černý; María Cerezo; Nuno M Silva; Martin Hájek; Alžběta Vašíková; Martina Kujanová; Radim Brdička et al. (17 March 2010). "Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel". European Journal of Human Genetics 18 (8): 915–923. doi:10.1038/ejhg.2010.21. PMID 20234393. 
  10. ↑ S. Plaza; F. Calafell; A. Helal; N. Bouzerna; G. Lefranc; J. Bertranpetit; D. Comas (July 2003). "Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean". Annals of Human Genetics 67 (4): 312–328. doi:10.1046/j.1469-1809.2003.00039.x. PMID 12914566. 
  11. ↑ "Mitochondrial DNA heterogeneity in Tunisian Berbers". Annals of Human Genetics 68 (Pt 3): 222–33. May 2004. doi:10.1046/j.1529-8817.2004.00096.x. PMID 15180702. 
  12. ↑ Asmahan Bekada; Lara R. Arauna; Tahria Deba; Francesc Calafell; Soraya Benhamamouch; David Comas (September 24, 2015). "Genetic Heterogeneity in Algerian Human Populations". PLOS ONE 10 (9): e0138453. doi:10.1371/journal.pone.0138453. PMID 26402429. Bibcode: 2015PLoSO..1038453B. ; S5 Table
  13. ↑ W. Haak et al., Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites, Science, vol. 310, no. 5750 (2005), pp. 1016-1018.
  14. ↑ W. Haak, et al., Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities, PLOS Biology, vol. 8, no.11 (November 2010), e1000536.
  15. ↑ A. V. Nedoluzhko, E. S. Boulygina, A. S. Sokolov, S. V. Tsygankova, N. M. Gruzdeva, A. D. Rezepkin, E. B. Prokhortchouk. Analysis of the Mitochondrial Genome of a Novosvobodnaya Culture Representative using Next-Generation Sequencing and Its Relation to the Funnel Beaker Culture
  16. ↑ A. G. Nikitin et al. (2010) Comprehensive site chronology and ancient Mitochondrial DNA analysis from Verteba cave – a trypillian culture site of eneolithic Ukraine
  17. ↑ Unetice Culture (c. 2300-1600 BCE)
  18. ↑ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology 14 (1): 109. doi:10.1186/1471-2148-14-109. PMID 24885141. Bibcode: 2014BMCEE..14..109S. 
  19. ↑ Template:GenBank
  20. ↑ Template:GenBank
  21. ↑ Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. pp. 118–119. doi:10.2307/j.ctv33mgbcn. ISBN 978-1644699843. 
  22. ↑ Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. pp. 119. doi:10.2307/j.ctv33mgbcn. ISBN 978-1644699843. 
  23. ↑ Template:GenBank
  24. ↑ Template:GenBank
  25. ↑ Template:GenBank
  26. ↑ Template:GenBank
  27. ↑ "PhyloTree.org | tree | R0". http://phylotree.org/tree/R0.htm. 
  28. ↑ Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. pp. 120–121. doi:10.2307/j.ctv33mgbcn. ISBN 978-1644699843. 
  29. ↑ Template:GenBank

External links



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