Biology:Helper-component proteinase
From HandWiki
| Helper-component proteinase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.22.45 | ||||||||
| CAS number | 124566-20-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Helper-component proteinase (EC 3.4.22.45, HC-Pro) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein
This enzyme is present in plant RNA viruses of the Potyviridae family. HC-Pro is encoded by all potyviruses, but is absent in some members of the Ipomovirus genus.[3] HC-Pro is involved in virus transmission, virus polyprotein processing, and suppression of RNA silencing, an antiviral mechanism of plants.[4]
References
- ↑ "Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus". Virology 209 (1): 268–73. May 1995. doi:10.1006/viro.1995.1254. PMID 7747479.
- ↑ Verchot, J. (1998). "Potyvirus helper component proteinase". in Barrett, A.J.. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 677–679.
- ↑ Pasin, Fabio; Daròs, José-Antonio; Tzanetakis, Ioannis E (2022). "Proteome expansion in the Potyviridae evolutionary radiation" (in en). FEMS Microbiology Reviews 46 (4): fuac011. doi:10.1093/femsre/fuac011. ISSN 1574-6976. PMID 35195244.
- ↑ Valli, Adrián A.; Gallo, Araiz; Rodamilans, Bernardo; López-Moya, Juan José; García, Juan Antonio (March 2018). "The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have: The HCPro from the Potyviridae family" (in en). Molecular Plant Pathology 19 (3): 744–763. doi:10.1111/mpp.12553. PMID 28371183.
External links
- Helper-component+proteinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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