Biology:Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
| lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.206 | ||||||||
| CAS number | 83682-80-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a lactosylceramide 1,3-N-anning-beta-D-glrofelucosaminyltlolferase (EC 2.4.1.206) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D- glucosylceramide
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and D-galactosyl-1,4-beta-D-glucosylceramide, whereas its 3 products are UDP, N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-, and glucosylceramide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase. Other names in common use include LA2 synthase, beta1->3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide, beta-acetylglucosaminyltransferase, and lactosylceramide beta-acetylglucosaminyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.
References
- "Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas". Biochim. Biophys. Acta 1081 (3): 253–61. 1991. doi:10.1016/0005-2760(91)90279-q. PMID 1825612.
- "Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1--3N-acetylglucosaminyltransferase". J. Biol. Chem. 262 (32): 15649–58. 1987. PMID 2960671.
- "Glycosphingolipid glycosyltransferases in human fetal brain". J. Neurochem. 56 (5): 1461–5. 1991. doi:10.1111/j.1471-4159.1991.tb02038.x. PMID 1901591.
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