Biology:Lipopolysaccharide N-acetylmannosaminouronosyltransferase
lipopolysaccharide N-acetylmannosaminouronosyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.4.1.180 | ||||||||
CAS number | 113478-30-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a lipopolysaccharide N-acetylmannosaminouronosyltransferase (EC 2.4.1.180) is an enzyme that catalyzes the chemical reaction
- UDP-N-acetyl-beta-D-mannosaminouronate + lipopolysaccharide [math]\displaystyle{ \rightleftharpoons }[/math] UDP + N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide
Thus, the two substrates of this enzyme are UDP-N-acetyl-beta-D-mannosaminouronate and lipopolysaccharide, whereas its two products are UDP and N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase. Other names in common use include ManNAcA transferase, uridine-diphosphoacetylmannosaminuronatetranferase, N-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase, and acetylmannosaminuronosyltransferase.
References
- "Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis". J. Bacteriol. 170 (1): 228–33. 1988. PMID 3275612.
![]() | Original source: https://en.wikipedia.org/wiki/Lipopolysaccharide N-acetylmannosaminouronosyltransferase.
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