Biology:Lysyl endopeptidase
From HandWiki
| Lysyl endopeptidase (R) | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.21.50 | ||||||||
| CAS number | 123175-82-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Lysyl endopeptidase (EC 3.4.21.50, Achromobacter proteinase I, Achromobacter lyticus alkaline proteinase I, protease I, achromopeptidase, lysyl bond specific proteinase, and caseinase) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Preferential cleavage: Lys-, including -Lys-Pro-
This enzyme is isolated from Lysobacter enzymogenes.
It is produced by the human body and by Achromobacter lyticus[7] that can help break down the protein casein in milk into smaller peptides and amino acids.[8]
References
- ↑ "Studies on a new proteolytic enzyme from A chromobacter lyticus M497-1. I. Purification and some enzymatic properties". Biochimica et Biophysica Acta 660 (1): 44–50. July 1981. doi:10.1016/0005-2744(81)90106-6. PMID 6791693.
- ↑ "Studies on a new proteolytic enzyme from Achromobacter lyticus M497-1. II. specificity and inhibition studies of Achromobacter protease I". Biochimica et Biophysica Acta 660 (1): 51–5. July 1981. doi:10.1016/0005-2744(81)90107-8. PMID 6168293.
- ↑ "Use of endoproteinase Lys-C from Lysobacter enzymogenes in protein sequence analysis". Analytical Biochemistry 134 (2): 347–54. October 1983. doi:10.1016/0003-2697(83)90308-1. PMID 6359954.
- ↑ "Isolation and characterization of a lysine-specific protease from Pseudomonas aeruginosa". The Journal of Biological Chemistry 261 (24): 11259–65. August 1986. doi:10.1016/S0021-9258(18)67377-6. PMID 3090046.
- ↑ "Cloning, nucleotide sequence, and expression of Achromobacter protease I gene". The Journal of Biological Chemistry 264 (34): 20625–31. December 1989. doi:10.1016/S0021-9258(19)47109-3. PMID 2684982.
- ↑ "The primary structure and structural characteristics of Achromobacter lyticus protease I, a lysine-specific serine protease". The Journal of Biological Chemistry 264 (7): 3832–9. March 1989. doi:10.1016/S0021-9258(19)84926-8. PMID 2492988.
- ↑ "BRENDA - Information on EC 3.4.21.50 - lysyl endopeptidase". http://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.50.
- ↑ "Caseinase Definition and Examples - Biology Online Dictionary". 7 October 2019. http://www.biology-online.org/dictionary/Caseinase.
External links
- Lysyl+endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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