Biology:N-methyl-2-oxoglutaramate hydrolase
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N-methyl-2-oxoglutaramate hydrolase | |||||||||
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Identifiers | |||||||||
EC number | 3.5.1.36 | ||||||||
CAS number | 9073-53-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-methyl-2-oxoglutaramate hydrolase (EC 3.5.1.36) is an enzyme that catalyzes the chemical reaction
- N-methyl-2-oxoglutaramate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxoglutarate + methylamine
Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H2O, whereas its two products are 2-oxoglutarate and methylamine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.
References
- Hersh LB (1970). "5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action". J. Biol. Chem. 245 (14): 3526–35. PMID 5470822.
- "The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid". J. Biol. Chem. 244 (17): 4677–83. 1969. PMID 5808511.
Original source: https://en.wikipedia.org/wiki/N-methyl-2-oxoglutaramate hydrolase.
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