Biology:Neuropeptide B

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[1][2] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

References

  1. "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system.". British Journal of Pharmacology 148 (8): 1033–41. Aug 2006. doi:10.1038/sj.bjp.0706825. PMID 16847439. 
  2. "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. 46. 2008. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. 

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