Biology:Peptidoglycan-N-acetylglucosamine deacetylase
From HandWiki
| Peptidoglycan-N-acetylglucosamine deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.104 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Peptidoglycan-N-acetylglucosamine deacetylase (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglycan deacetylase, N-acetylglucosamine deacetylase, peptidoglycan GlcNAc deacetylase, peptidoglycan N-acetylglucosamine deacetylase, PG N-deacetylase) is an enzyme with systematic name peptidoglycan-N-acetylglucosamine amidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- peptidoglycan-N-acetyl-D-glucosamine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] peptidoglycan-D-glucosamine + acetate
This enzyme contributes to virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis.
References
- ↑ "Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis". The Journal of Biological Chemistry 280 (35): 30856–63. September 2005. doi:10.1074/jbc.m407426200. PMID 15961396.
- ↑ "Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6". Acta Crystallographica Section F 64 (Pt 3): 203–5. March 2008. doi:10.1107/s1744309108002510. PMID 18323609.
- ↑ "Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor". Proceedings of the National Academy of Sciences of the United States of America 102 (43): 15429–34. October 2005. doi:10.1073/pnas.0504339102. PMID 16221761.
- ↑ "Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori". The Journal of Biological Chemistry 284 (11): 6790–800. March 2009. doi:10.1074/jbc.m808071200. PMID 19147492.
- ↑ "Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis". Journal of Microbiology and Biotechnology 19 (9): 932–45. September 2009. doi:10.4014/jmb.0810.557. PMID 19809250.
- ↑ "Significant contribution of the pgdA gene to the virulence of Streptococcus suis". Molecular Microbiology 70 (5): 1120–35. December 2008. doi:10.1111/j.1365-2958.2008.06463.x. PMID 18990186.
External links
- Peptidoglycan-N-acetylglucosamine+deacetylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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