Biology:Physarolisin
From HandWiki
| Physarolisin | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.21.103 | ||||||||
| CAS number | 94949-28-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Physarolisin (EC 3.4.21.103, Dictyostelium discoideum aspartic proteinase, Dictyostelium discoideum aspartic proteinase E, Physarum flavicomum aspartic proteinase, Physarum polycephalum acid proteinase, Physarum aspartic proteinase, physaropepsin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Milk clotting activity. Preferential cleavage of Gly8-Ser in B chain of insulin most rapidly, followed by Leu11!Val, Cys(SO3H)19-Gly and Phe24-Phe.
This enzyme belongs in peptidase family S53.
References
- ↑ "Purification and some properties of an intracellular acid (carboxyl) proteinase from differentiating haploid cells of Physarum flavicomum". Exp. Mycol. 6: 161–170. 1982. doi:10.1016/0147-5975(82)90090-1.
- ↑ "A novel acid protease from haploid amoebae of Physarum polycephalum, and its changes during mating and subsequent differentiation into diploid plasmodia". Cell Struct. Funct. 9: 311–315. 1984. doi:10.1247/csf.9.311.
- ↑ "Purification and characterization of two acid proteinases from Dictyostelium discoideum". J. Gen. Microbiol. 130: 123–134. 1984. doi:10.1099/00221287-130-1-123.
- ↑ "Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases". Acta Biochimica Polonica 50 (1): 81–102. 2003. PMID 12673349. http://www.actabp.pl/pdf/1_2003/81.pdf.
- ↑ "Structural and enzymatic characterization of physarolisin (formerly physaropepsin) proves that it is a unique serine-carboxyl proteinase". Biochemical and Biophysical Research Communications 301 (4): 1023–9. February 2003. doi:10.1016/s0006-291x(03)00083-4. PMID 12589815.
External links
- Physarolisin at the US National Library of Medicine Medical Subject Headings (MeSH)
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