Biology:Precorrin-3B synthase
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Short description: Class of enzymes
| Precorrin-3B synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Precorrin-3B synthase (EC 1.14.13.83) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The four substrates of this enzyme are precorrin-3A, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are precorrin-3B, oxidised NAD+, and water.[1][2][3]
This enzyme is an iron–sulfur protein acting as an oxidoreductase, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating). Other names in common use include precorrin-3X synthase, and CobG. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.[4]
See also
References
- ↑ "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22): 7430–40. 1993. doi:10.1128/jb.175.22.7430-7440.1993. PMID 8226690.
- ↑ "Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group". FEBS Lett. 331 (1–2): 105–8. 1993. doi:10.1016/0014-5793(93)80306-F. PMID 8405386. Bibcode: 1993FEBSL.331..105S.
- ↑ "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. 2002. doi:10.1039/b108967f. PMID 12195810.
- ↑ Enzyme 1.14.13.83 at KEGG Pathway Database.
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