Biology:Procollagen galactosyltransferase
procollagen galactosyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.4.1.50 | ||||||||
CAS number | 9028-07-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a procollagen galactosyltransferase (EC 2.4.1.50) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + procollagen 5-hydroxy-L-lysine [math]\displaystyle{ \rightleftharpoons }[/math] UDP + procollagen 5-(D-galactosyloxy)-L-lysine
Thus, the two substrates of this enzyme are UDP-galactose and procollagen 5-hydroxy-L-lysine, whereas its two products are UDP and procollagen 5-(D-galactosyloxy)-L-lysine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase. Other names in common use include hydroxylysine galactosyltransferase, collagen galactosyltransferase, collagen hydroxylysyl galactosyltransferase, UDP galactose-collagen galactosyltransferase, uridine diphosphogalactose-collagen galactosyltransferase, and UDPgalactose:5-hydroxylysine-collagen galactosyltransferase. This enzyme participates in lysine degradation.
References
- "Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen". Biochem. Biophys. Res. Commun. 33 (2): 340–6. 1968. doi:10.1016/0006-291X(68)90790-0. PMID 5722225.
- Kivirikko KI; Myllyla R (1979). Hall, D.A.. ed. "Collagen glycosyltransferases". International Review of Connective Tissue Research (New York: Academic Press) 8: 23–72. doi:10.1016/B978-0-12-363708-6.50008-4. ISBN 9780123637086. PMID 389860.
![]() | Original source: https://en.wikipedia.org/wiki/Procollagen galactosyltransferase.
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