Biology:Zinc finger and BTB domain-containing protein 16
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Short description: Protein found in humans
 Generic protein structure example |
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[1] and physiological roles have been identified in mouse Natural Killer T cells[2][3] and gamma-delta T cells.[4] Alternate transcriptional splice variants have been characterized in human.[5][6]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:
- Angiotensin II receptor type 1,[7]
- BCL6,[8]
- BMI1,[9]
- Calcitriol receptor,[10][11]
- FHL2,[12]
- GATA1,[13]
- GATA2,[14]
- HDAC1,[15][16][17]
- HDAC4,[15][18]
- HDAC5,[15][18]
- HDAC6,[15]
- Heparin-binding EGF-like growth factor,[19][20]
- Nuclear receptor co-repressor 2,[17][21][22]
- Promyelocytic leukemia protein[23]
- RUNX1T1,[24][25]
- Retinoic acid receptor alpha,[26]
- SIN3A,[10][16][17]
- SIN3B,[16] and
- ZBTB32.[27]
See also
References
- ↑ "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal 12 (3): 1161–7. 1993. doi:10.1002/j.1460-2075.1993.tb05757.x. PMID 8384553.
- ↑ "The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions". Nature Immunology 9 (9): 1055–64. 2008. doi:10.1038/ni.1641. PMID 18660811.
- ↑ "The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage". Immunity 29 (3): 391–403. 2008. doi:10.1016/j.immuni.2008.07.011. PMID 18703361.
- ↑ "TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity". Proceedings of the National Academy of Sciences of the United States of America 106 (30): 12453–8. 2009. doi:10.1073/pnas.0903895106. PMID 19617548. Bibcode: 2009PNAS..10612453K.
- ↑ "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11422–7. 1999. doi:10.1073/pnas.96.20.11422. PMID 10500192. Bibcode: 1999PNAS...9611422Z.
- ↑ "ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7704.
- ↑ "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy". EMBO J. 22 (24): 6471–82. 2003. doi:10.1093/emboj/cdg637. PMID 14657020.
- ↑ "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene 19 (54): 6240–50. 2000. doi:10.1038/sj.onc.1203976. PMID 11175338.
- ↑ "Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling". Dev. Cell 3 (4): 499–510. 2002. doi:10.1016/s1534-5807(02)00289-7. PMID 12408802.
- ↑ 10.0 10.1 "The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor". Blood 98 (12): 3290–300. 2001. doi:10.1182/blood.v98.12.3290. PMID 11719366.
- ↑ "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. 2002. PMID 12460926.
- ↑ "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. 277 (40): 37045–53. 2002. doi:10.1074/jbc.M203336200. PMID 12145280.
- ↑ "PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein". Oncogene 21 (43): 6669–79. 2002. doi:10.1038/sj.onc.1205884. PMID 12242665.
- ↑ "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood 99 (9): 3404–10. 2002. doi:10.1182/blood.v99.9.3404. PMID 11964310.
- ↑ 15.0 15.1 15.2 15.3 "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene 23 (54): 8777–84. 2004. doi:10.1038/sj.onc.1208128. PMID 15467736.
- ↑ 16.0 16.1 16.2 "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. 1998. doi:10.1038/sj.onc.1202043. PMID 9627120.
- ↑ 17.0 17.1 17.2 "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. 1998. doi:10.1074/jbc.273.42.27695. PMID 9765306.
- ↑ 18.0 18.1 "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. 2002. doi:10.1074/jbc.M201736200. PMID 11929873. https://hal.archives-ouvertes.fr/hal-00379714/file/Lemercier_BCL6_JBC_2002._doc.pdf.
- ↑ "Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF". J. Cell Biol. 163 (3): 489–502. 2003. doi:10.1083/jcb.200303017. PMID 14597771.
- ↑ "Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF". Biochem. Biophys. Res. Commun. 320 (2): 376–82. 2004. doi:10.1016/j.bbrc.2004.05.176. PMID 15219838.
- ↑ "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood 103 (12): 4650–8. 2004. doi:10.1182/blood-2003-08-2759. PMID 14982881.
- ↑ "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. 1997. doi:10.1073/pnas.94.17.9028. PMID 9256429. Bibcode: 1997PNAS...94.9028H.
- ↑ "Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10255–60. 1997. doi:10.1073/pnas.94.19.10255. PMID 9294197. Bibcode: 1997PNAS...9410255K.
- ↑ "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. 2000. doi:10.1128/mcb.20.6.2075-2086.2000. PMID 10688654.
- ↑ "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood 96 (12): 3939–47. 2000. doi:10.1182/blood.V96.12.3939. PMID 11090081.
- ↑ "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. 2003. doi:10.1186/1478-1336-1-6. PMID 14521715.
- ↑ "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood 94 (11): 3737–47. 1999. doi:10.1182/blood.V94.11.3737. PMID 10572087.
Further reading
- "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal 12 (3): 1161–7. 1993. doi:10.1002/j.1460-2075.1993.tb05757.x. PMID 8384553.
- "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia". The Journal of Clinical Investigation 91 (5): 2260–7. 1993. doi:10.1172/JCI116453. PMID 8387545.
- "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors". Blood 86 (12): 4544–52. 1995. doi:10.1182/blood.V86.12.4544.bloodjournal86124544. PMID 8541544.
- "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein". Proceedings of the National Academy of Sciences of the United States of America 93 (8): 3624–9. 1996. doi:10.1073/pnas.93.8.3624. PMID 8622986. Bibcode: 1996PNAS...93.3624D.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America 94 (17): 9028–33. 1997. doi:10.1073/pnas.94.17.9028. PMID 9256429. Bibcode: 1997PNAS...94.9028H.
- "Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proceedings of the National Academy of Sciences of the United States of America 94 (19): 10255–60. 1997. doi:10.1073/pnas.94.19.10255. PMID 9294197. Bibcode: 1997PNAS...9410255K.
- "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature 391 (6669): 811–4. 1998. doi:10.1038/35895. PMID 9486654. Bibcode: 1998Natur.391..811L.
- "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood 91 (8): 2634–42. 1998. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
- "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. 1998. doi:10.1038/sj.onc.1202043. PMID 9627120.
- "Crystal structure of the BTB domain from PLZF". Proceedings of the National Academy of Sciences of the United States of America 95 (21): 12123–8. 1998. doi:10.1073/pnas.95.21.12123. PMID 9770450. Bibcode: 1998PNAS...9512123F.
- "Genomic structure of the human PLZF gene". Gene 236 (1): 21–4. 1999. doi:10.1016/S0378-1119(99)00277-2. PMID 10433962.
- "The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase". Nucleic Acids Research 27 (20): 4106–13. 1999. doi:10.1093/nar/27.20.4106. PMID 10497277.
- "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11422–7. 1999. doi:10.1073/pnas.96.20.11422. PMID 10500192. Bibcode: 1999PNAS...9611422Z.
- "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Research 59 (20): 5275–82. 1999. PMID 10537309.
- "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood 94 (11): 3737–47. 1999. doi:10.1182/blood.V94.11.3737. PMID 10572087.
- "The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein". Molecular and Cellular Biology 20 (6): 2075–86. 2000. doi:10.1128/MCB.20.6.2075-2086.2000. PMID 10688654.
- "Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)". The Journal of Cell Biology 149 (3): 537–46. 2000. doi:10.1083/jcb.149.3.537. PMID 10791968.
- "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood 96 (12): 3939–47. 2000. doi:10.1182/blood.V96.12.3939. PMID 11090081.
- "Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides". PLOS ONE 7 (11): e48636. 2012. doi:10.1371/journal.pone.0048636. PMID 23152790. Bibcode: 2012PLoSO...748636B.
- "Two critical hits for promyelocytic leukemia". Molecular Cell 6 (5): 1131–41. 2000. doi:10.1016/S1097-2765(00)00111-8. PMID 11106752.
External links
- ZBTB16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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