Biology:Small temporal RNA

From HandWiki

Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated.[1] In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability.[2] Nowadays, stRNAs are better known as miRNAs. stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their roles in RNA interference (RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms.[3]

References

  1. ↑ "Development. Dicing up RNAs". Science 293 (5531): 811–3. August 2001. doi:10.1126/science.1064400. PMID 11486075. 
  2. ↑ "Micro-RNAs: small is plentiful". The Journal of Cell Biology 156 (1): 17–21. January 2002. doi:10.1083/jcb.200111033. PMID 11781331. 
  3. ↑ "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". BioEssays 24 (2): 119–29. February 2002. doi:10.1002/bies.10046. PMID 11835276. 



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