Biology:Urate-ribonucleotide phosphorylase
From HandWiki
Short description: Enzyme in purine metabolism
| urate-ribonucleotide phosphorylase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.2.16 | ||||||||
| CAS number | 9030-29-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an urate-ribonucleotide phosphorylase (EC 2.4.2.16) is an enzyme that catalyzes the chemical reaction
- urate D-ribonucleotide + phosphate [math]\displaystyle{ \rightleftharpoons }[/math] urate + alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are urate D-ribonucleotide and phosphate, whereas its two products are urate and alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is urate-ribonucleotide:phosphate alpha-D-ribosyltransferase. Other names in common use include UAR phosphorylase, and urate-ribonucleotide:phosphate D-ribosyltransferase. This enzyme participates in purine metabolism.
References
- "An intestinal phosphorylase for uric acid ribonucleoside". The Journal of Biological Chemistry 238: 3348–57. October 1963. PMID 14085385.
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