Biology:Ureidoglycolate hydrolase

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In enzymology, an ureidoglycolate hydrolase (EC is an enzyme that catalyzes the chemical reaction

(S)-ureidoglycolate + H2O [math]\rightleftharpoons[/math] glyoxylate + 2 NH3 + CO2

Thus, the two substrates of this enzyme are (S)-ureidoglycolate and H2O, whereas its 3 products are glyoxylate, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is (S)-ureidoglycolate amidohydrolase (decarboxylating). This enzyme participates in purine metabolism.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XSQ, 1XSR, 1YQC, and 2BDR.

References[edit] hydrolase was the original source. Read more.