Chemistry:Phenindione

From HandWiki
Short description: Chemical compound
Phenindione
Phenindione.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: D
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Protein binding88%
Elimination half-life5 to 10 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC15H10O2
Molar mass222.243 g·mol−1
3D model (JSmol)
  (verify)

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]

References

  1. "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics 313 (3): 1058–65. June 2005. doi:10.1124/jpet.105.083758. PMID 15743920. 
  2. Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. 2009. "Phenindione", p. 1369. 

External links