Chemistry:Coumatetralyl

Coumatetralyl

Names
IUPAC name (RS)-2-Hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-4H-chromen-4-one
Identifiers
CAS Number	5836-29-3 Y
3D model (JSmol)	Interactive image
ChemSpider	10468736 Y
KEGG	C16806 Y
PubChem CID	54678504
UNII	NWK4HW86A8 Y
InChI InChI=1S/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2 Y Key: ULSLJYXHZDTLQK-UHFFFAOYSA-N Y InChI=1/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2 Key: ULSLJYXHZDTLQK-UHFFFAOYAA
SMILES OC=1c4ccccc4OC(=O)C=1C3CCCc2ccccc23
Properties
Chemical formula	C19H16O3
Molar mass	292.334 g·mol−1
Hazards
GHS pictograms
GHS Signal word	Danger
GHS hazard statements	HH300Category:GHS errors, HH311Category:GHS errors, HH330Category:GHS errors, HH360DCategory:GHS errors, HH372Category:GHS errors, HH410Category:GHS errors
GHS precautionary statements	PP201Category:GHS errors, PP202Category:GHS errors, PP260Category:GHS errors, PP264Category:GHS errors, PP270Category:GHS errors, PP271Category:GHS errors, PP273Category:GHS errors, PP280Category:GHS errors, PP281Category:GHS errors, PP284Category:GHS errors, PP301+P310Category:GHS errors, PP302+P352Category:GHS errors, PP304+P340Category:GHS errors, PP308+P313Category:GHS errors, PP310Category:GHS errors, PP312Category:GHS errors, PP314Category:GHS errors, PP320Category:GHS errors, PP321Category:GHS errors, PP322Category:GHS errors, PP330Category:GHS errors, PP361Category:GHS errors, PP363Category:GHS errors, PP391Category:GHS errors, PP403+P233Category:GHS errors
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide.

Common applications

Coumatetralyl is commonly used with grains and other cereals as a rodent poison in conjunction with a tracking powder to monitor feeding activity in a particular area. Tracking powder also clings to fur, which allows more poison to be ingested from grooming. Concentrations of the chemical are usually 500 mg per 1 kg of bait.

Rat poison grains

Toxicity to humans

Symptoms of overexposure relate to failure of the blood clotting mechanism and include bleeding gums and failure of blood clotting after skin wounds. After one exposure the toxicity of coumatetralyl is relatively low; however, if overexposure continues for several days the product becomes more toxic. The product must therefore be constantly present in the bloodstream for more than one to two days in order to be highly toxic. A single exposure, even though relatively large, may not produce toxic symptoms as the compound is quite rapidly metabolized.

Chronic animal studies show no evidence of carcinogenic or teratogenic effects.

Treatment

Vitamin K₁ (phylloquinone) is antidotal.

See also

• C₁₉H₁₆O₃