Chemistry:Flumedroxone acetate
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| Trade names | Demigran, Leomigran |
| Other names | WG-537; 6α-(Trifluoromethyl)-17α-acetoxyprogesterone; 6α-(Trifluoromethyl)-17α-acetoxypregn-4-ene-3,20-dione |
| Routes of administration | By mouth[1] |
| Drug class | Progestogen; Progestin; Progestogen ester |
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| Chemical and physical data | |
| Formula | C24H31F3O4 |
| Molar mass | 440.503 g·mol−1 |
| 3D model (JSmol) | |
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Flumedroxone acetate, sold under the brand names Demigran and Leomigran, is a progestin medication which is or has been used as an antimigraine agent.[2][3][4] It is taken by mouth.[1]
Medical uses
Flumedroxone acetate has been assessed in over 1,000 patients for the treatment of migraine, with effectiveness ranging from excellent to less than that of the reference antimigraine drug methysergide.[5] Other progestogens including medroxyprogesterone acetate, lynestrenol, allylestrenol, dydrogesterone, and normethandrone have also been found to be effective for migraine in a high percentage of women.[5]
Side effects
In accordance with its progestogenic activity, flumedroxone acetate produces menstrual irregularities, namely polymenorrhea, and breast tension as side effects in women.[5][6][7]
Pharmacology
Pharmacodynamics
Flumedroxone acetate is said to have weak or slight progestogenic activity without other hormonal activity, including no estrogenic, antiestrogenic, androgenic, anabolic, or glucocorticoid activity.[5][1]
Chemistry
Flumedroxone acetate, also known as 6α-(trifluoromethyl)-17α-acetoxyprogesterone or as 6α-(trifluoromethyl)-17α-acetoxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[2] It is specifically a derivative of 17α-hydroxyprogesterone with a trifluoromethyl group at the C6α position and an acetate ester attached to the C17α hydroxyl group.[3] The medication is the C17α acetate ester of flumedroxone (6α-(trifluoromethyl)-17α-hydroxyprogesterone) and the C6α trifluoromethyl derivative of hydroxyprogesterone acetate (17α-acetoxyprogesterone).[2]
History
Flumedroxone acetate was introduced for medical use in the 1960s.[4]
Society and culture
Generic names
Flumedroxone is the INN and BAN of the free alcohol form of the drug, flumedroxone.[2] Flumedroxone acetate is also known by its developmental code name WG-537.[2]
Brand names
Flumedroxone acetate is or has been marketed under the brand names Demigran and Leomigran.[2][4]
Availability
Flumedroxone acetate is or has been marketed in Europe.[4]
See also
References
- ↑ 1.0 1.1 1.2 Headache and facial pain: differential diagnosis, pathogenesis, treatment. Year Book Medical. 1981. p. 97. ISBN 978-3-13-589501-7. https://books.google.com/books?id=B69pAAAAMAAJ. "Lundberg (1969) recommended the oral application of a steroid (flumedroxone) which has only a weak progesterone effect and does not display any other gonadotropic effects."
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 560–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA560.
- ↑ 3.0 3.1 "Drugs for Endocrine and Metabolic Disorders". Bioorganic and Medicinal Chemistry of Fluorine. John Wiley & Sons. 2 June 2008. pp. 329–. ISBN 978-0-470-28187-1. https://books.google.com/books?id=QMVSvZ-R7I0C&pg=PA329.
- ↑ 4.0 4.1 4.2 4.3 "Controlled trial of demigran in the prophylaxis of migraine". British Medical Journal 2 (5544): 91–93. April 1967. doi:10.1136/bmj.2.5544.91. PMID 6020856.
- ↑ 5.0 5.1 5.2 5.3 "Endocrinology of Headache: A Review". Updating in Headache. Springer Science & Business Media. 6 December 2012. pp. 229–. ISBN 978-3-642-88581-5. https://books.google.com/books?id=czSSBgAAQBAJ&pg=PA229.
- ↑ "Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine". British Medical Journal 3 (5617): 531–533. August 1968. doi:10.1136/bmj.3.5617.531. PMID 4877801.
- ↑ "Prophylactic treatment of migraine with flumedroxone". Acta Neurologica Scandinavica 45 (3): 309–326. 1969. doi:10.1111/j.1600-0404.1969.tb01243.x. PMID 5817457.
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