Chemistry:Oxetorone

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Short description: Chemical compound
Oxetorone
Skeletal formula of oxetorone
Space-filling model of the oxetorone molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC21H21NO2
Molar mass319.404 g·mol−1
3D model (JSmol)
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Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug.[1][2][3][4] Association with hyperprolactinemia has been described[5] and antidopaminergic actions are also suspected.[6]

References

  1. ↑ Dictionary of Pharmacological Agents. CRC Press. 21 November 1996. pp. 1493–. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1493. 
  2. ↑ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. pp. 2935–. ISBN 978-0-8155-1856-3. https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA2935-IA131. 
  3. ↑ Drug Benefits and Risks: International Textbook of Clinical Pharmacology (Revised 2nd ed.). IOS Press. 6 August 2008. pp. 699–. ISBN 978-1-60750-345-3. https://books.google.com/books?id=idbvAgAAQBAJ&pg=PA699. 
  4. ↑ "[Prophylactic treatments of migraine"] (in fr). Revue Neurologique 156 (Suppl 4): 4S79–86. 2000. PMID 11139754. http://www.masson.fr/masson/79997. 
  5. ↑ "Hyperprolactinaemia and depression induced by oxetorone". Cephalalgia 16 (8): 560–1. December 1996. doi:10.1046/j.1468-2982.1996.1608560.x. PMID 8980859. 
  6. ↑ "New evidence for oxetorone toxicity". Clin Toxicol (Phila) 55 (2): 142–146. February 2017. doi:10.1080/15563650.2016.1267358. PMID 27967233. 





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