Chemistry:Polyhexanide
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| Names | |
|---|---|
| Other names
Polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide
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| Identifiers | |
| Abbreviations | PHMB |
| ChEBI | |
| ChemSpider |
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| UNII | |
| Properties | |
| (C8H17N5)n | |
| Pharmacology | |
| 1=ATC code }} | D08AC05 (WHO) S01AX24 (WHO) |
| Hazards | |
| GHS pictograms |     
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| GHS Signal word | danger |
| H410, H318, H351, H317, H372, H330, H302 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use,[2] it is spelled polihexanide (INN) and sold under the names Lavasept, Serasept, Prontosan, and Omnicide.[3] PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.[4]
Products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.[5] PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.[6]
It is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The PHMB hydrochloride salt (solution) is used in the majority of formulations.
Safety
In 2011, Polyhexamethylenbiguanide was classified as category 2 carcinogen by the European Chemical Agency, but it is still allowed in cosmetics in small quantities if exposure by inhalation is impossible.
See also
References
- ↑ "Classification and Labelling of PHMB". European Chemicals Agency. https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/91740.
- ↑ "Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin". Arzneimittel-Forschung 53 (5): 368–71. 2003. doi:10.1055/s-0031-1297121. PMID 12854364.
- ↑ International Drug Names: Polihexanide
- ↑ Maribeth Cousin, Kimberly Restivo, Chelsea Rodriguez, and Justin Lien. USP Antimicrobial Effectiveness Test (GLP). Elkhorn, WI: Geneva Laboratories. 2013. "Archived copy". http://steriwebrx.com/files/STERIWEB-FINAL-JN13J1514.pdf.
- ↑ "Nusept". http://www.tulipgroup.com/Bioshields2/html/antiseptics_nusept.htm.
- ↑ "Medical interventions for acanthamoeba keratitis". Cochrane Database Syst Rev 2 (2): CD0010792. 2015. doi:10.1002/14651858.CD010792.pub2. PMID 25710134.
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