Chemistry:Fenticlor
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Short description: Chemical compound
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| Routes of administration | topical |
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| Formula | C12H8Cl2O2S |
| Molar mass | 287.15 g·mol−1 |
| Melting point | 174 °C (345 °F) |
Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine.
Synthesis
It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride.[1] It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.[2][3]
Safety
LD50 (rats, oral) = 3250 mg/kg.[1] It may cause photosensitivity[4]
References
- ↑ 1.0 1.1 "Ullmann's Encyclopedia of Industrial Chemistry". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. 2007. doi:10.1002/14356007.a19_313.
- ↑ Muth F, "Verfahren zur Darstellung von Bis-(halogen-oxyaryl)-sulfiden", DE patent 568944, issued 1931, assigned to I. G. Farben
- ↑ "Preparation and Bacteriological Study of Some Symmetrical Organic Sulfides". Journal of the American Chemical Society 53 (9): 3466–3469. 1931. doi:10.1021/ja01360a035.
- ↑ "Letter: Fenticlor, actinic reticuloid, and antihistamines". British Medical Journal 2 (5918): 556–7. June 1974. doi:10.1136/bmj.2.5918.556-c. PMID 4152080.
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