Chemistry:Ornidazole
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Trade names | Xynor |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Metabolism | Via liver[1]:1356 |
| Elimination half-life | 12-13 hours[1]:1356 |
| Excretion | Urine (63%) and Feces (22%) |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C7H10ClN3O3 |
| Molar mass | 219.63 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Ornidazole is an antibiotic used to treat protozoan infections.[1]:1368 A synthetic nitroimidazole, it is commercially obtained from an acid-catalyzed reaction between 2-methyl-5-nitroimidazole and epichlorohydrin.[2]
Antimicrobial spectrum is similar to that of metronidazole and is more well tolerated;[1]:1368 however there are concerns of lower relative efficacy.[3]
It was first introduced for treating trichomoniasis before being recognized for its broad anti-protozoan and anti-anaerobic-bacterial capacities.[4]:1261 has also been investigated for use in Crohn's disease after bowel resection.[5]
References
- ↑ 1.0 1.1 1.2 1.3 "157 - Antiparasitic Agents". Infectious Diseases (Fourth ed.). Elsevier. 2017-01-01. pp. 1345–1372.e2. doi:10.1016/B978-0-7020-6285-8.00157-X. ISBN 978-0-7020-6285-8. http://www.sciencedirect.com/science/article/pii/B978070206285800157X.
- ↑ "Chapter 17 - Nitroheterocycles". Pharmacochemistry Library. Approaches to Design and Synthesis of Antiparasitic Drugs. 25. Elsevier. January 1997. pp. 428. doi:10.1016/S0165-7208(97)80039-6. ISBN 9780444894762.
- ↑ "28 - Metronidazole". Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth ed.). Content Repository Only!. January 2015. pp. 356. ISBN 978-1-4557-4801-3.
- ↑ "147 - Nitroimidazoles, Metronidazole, Ornidazole and Tinidazole; and Fidaxomicin", Infectious Diseases (Fourth ed.), Elsevier, January 2017, pp. 1261–1263.e1, ISBN 978-0-7020-6285-8
- ↑ "Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial". Gastroenterology 128 (4): 856–861. April 2005. doi:10.1053/j.gastro.2005.01.010. PMID 15825069.
 |  |
