Biology:ADCY9

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.

External links

• Human ADCY9 genome location and ADCY9 gene details page in the UCSC Genome Browser.

Further reading

• "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• "Control of a novel adenylyl cyclase by calcineurin.". Biochem. Biophys. Res. Commun. 214 (3): 1000–8. 1995. doi:10.1006/bbrc.1995.2385. PMID 7575502. 
• "Identification and characterization of a widely expressed form of adenylyl cyclase.". J. Biol. Chem. 271 (23): 13900–7. 1996. doi:10.1074/jbc.271.23.13900. PMID 8662814. 
• "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. 1998. doi:10.1093/dnares/5.1.31. PMID 9628581. 
• "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflügers Arch. 437 (4): 538–46. 1999. doi:10.1007/s004240050815. PMID 10089566. 
• "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. 2000. doi:10.1097/00002030-200004140-00001. PMID 10807185. 
• "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. 2000. doi:10.1067/mai.2000.105315. PMID 10808179. 
• "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. 2001. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. 
• "Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders.". Am. J. Med. Genet. 114 (1): 84–92. 2002. doi:10.1002/ajmg.10117. PMID 11840511. 
• "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. 2002. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542. 
• "Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder". Mol. Psychiatry 7 (5): 450–2. 2002. doi:10.1038/sj.mp.4000992. PMID 12082561. 
• "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. 2003. doi:10.1081/RRS-120014589. PMID 12503609. 
• "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation". Pharmacogenetics 13 (9): 535–41. 2004. doi:10.1097/00008571-200309000-00002. PMID 12972952. 
• "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): 108–15. 2004. doi:10.1124/jpet.104.065748. PMID 14996950. 
• "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways". Hum. Mol. Genet. 14 (12): 1671–7. 2005. doi:10.1093/hmg/ddi175. PMID 15879435. 
• "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.