Biology:NCOA4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene.[1][2][3] It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
Interactions
NCOA4 has been shown to interact with:
- Androgen receptor,[2][4][5][6][7][8][9][10][11] and
- Peroxisome proliferator-activated receptor gamma[12]
- Ferritin[13][14]
- ATG8[15]
See also
References
- ↑ "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. February 1994. PMID 8290261.
- ↑ 2.0 2.1 "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5517–21. May 1996. doi:10.1073/pnas.93.11.5517. PMID 8643607. Bibcode: 1996PNAS...93.5517Y.
- ↑ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031.
- ↑ "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology 13 (1): 117–28. January 1999. doi:10.1210/mend.13.1.0214. PMID 9892017.
- ↑ "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. June 1998. doi:10.1073/pnas.95.13.7379. PMID 9636157. Bibcode: 1998PNAS...95.7379M.
- ↑ "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. June 2001. doi:10.1073/pnas.121173298. PMID 11404460. Bibcode: 2001PNAS...98.7200L.
- ↑ "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. May 1999. doi:10.1073/pnas.96.10.5458. PMID 10318905. Bibcode: 1999PNAS...96.5458Y.
- ↑ "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology 16 (2): 287–300. February 2002. doi:10.1210/mend.16.2.0765. PMID 11818501.
- ↑ "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry 277 (12): 10226–35. March 2002. doi:10.1074/jbc.M111975200. PMID 11779876.
- ↑ "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology 13 (10): 1645–56. October 1999. doi:10.1210/mend.13.10.0352. PMID 10517667.
- ↑ "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology 23 (6): 2135–50. March 2003. doi:10.1128/mcb.23.6.2135-2150.2003. PMID 12612084.
- ↑ "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 274 (23): 16147–52. June 1999. doi:10.1074/jbc.274.23.16147. PMID 10347167.
- ↑ "Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy". Nature 509 (7498): 105–9. May 2014. doi:10.1038/nature13148. PMID 24695223. PMC 4180099. Bibcode: 2014Natur.509..105M. https://dash.harvard.edu/bitstream/handle/1/13454816/4180099.pdf?sequence=1.
- ↑ "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo". Nature Cell Biology 16 (11): 1069–79. November 2014. doi:10.1038/ncb3053. PMID 25327288.
- ↑ "NCOA4 Deficiency Impairs Systemic Iron Homeostasis". Cell Reports 14 (3): 411–421. January 2016. doi:10.1016/j.celrep.2015.12.065. PMID 26776506.
Further reading
- "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2". Genes, Chromosomes & Cancer 11 (1): 51–7. September 1994. doi:10.1002/gcc.2870110108. PMID 7529046.
- "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma". Cancer Letters 78 (1–3): 69–76. April 1994. doi:10.1016/0304-3835(94)90033-7. PMID 8180971.
- "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas". Cancer Research 54 (11): 2979–85. June 1994. PMID 8187085.
- "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas". Genomics 42 (2): 252–9. June 1997. doi:10.1006/geno.1997.4685. PMID 9192845.
- "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. June 1998. doi:10.1073/pnas.95.13.7379. PMID 9636157. Bibcode: 1998PNAS...95.7379M.
- "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology 13 (1): 117–28. January 1999. doi:10.1210/mend.13.1.0214. PMID 9892017.
- "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". The Journal of Biological Chemistry 274 (13): 8570–6. March 1999. doi:10.1074/jbc.274.13.8570. PMID 10085091.
- "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. May 1999. doi:10.1073/pnas.96.10.5458. PMID 10318905. Bibcode: 1999PNAS...96.5458Y.
- "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 274 (23): 16147–52. June 1999. doi:10.1074/jbc.274.23.16147. PMID 10347167.
- "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology 13 (10): 1645–56. October 1999. doi:10.1210/mend.13.10.0352. PMID 10517667.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. September 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. June 2001. doi:10.1073/pnas.121173298. PMID 11404460. Bibcode: 2001PNAS...98.7200L.
- "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma". The American Journal of Pathology 160 (1): 247–54. January 2002. doi:10.1016/S0002-9440(10)64368-4. PMID 11786418.
- "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology 16 (2): 287–300. February 2002. doi:10.1210/mend.16.2.0765. PMID 11818501.
- "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation". The Journal of Biological Chemistry 277 (39): 36499–508. September 2002. doi:10.1074/jbc.M202824200. PMID 12068007.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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