Biology:BCAS3
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Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[1][2] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[2]
Function
The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[3] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[4] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[4]
References
- ↑ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54828.
- ↑ 2.0 2.1 "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. December 2002. doi:10.1002/gcc.10121. PMID 12378525.
- ↑ "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. April 2006. doi:10.1073/pnas.0601989103. PMID 16617102. Bibcode: 2006PNAS..103.6670G.
- ↑ 4.0 4.1 "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. August 2007. doi:10.1210/me.2006-0514. PMID 17505058.
External links
- Human BCAS3 genome location and BCAS3 gene details page in the UCSC Genome Browser.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. 2003. doi:10.1002/gcc.10121. PMID 12378525.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. 2006. doi:10.1073/pnas.0601989103. PMID 16617102. Bibcode: 2006PNAS..103.6670G.
- "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle 5 (13): 1407–10. 2006. doi:10.4161/cc.5.13.2924. PMID 16855396.
- "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. 2007. doi:10.1210/me.2006-0514. PMID 17505058.
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