Chemistry:Olcegepant

Olcegepant
Clinical data
ATC code	None;
Identifiers
	IUPAC name N-[(1R)-2-[[(1S)-5-Amino-1-[[4-(pyridin-4-yl)piperazin-1-yl]carbonyl]pentyl]amino]-1-(3,5-dibromo-4-hydroxybenzyl)-2-oxoethyl]-4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide;
CAS Number	204697-65-4;
PubChem CID	6918509;
ChemSpider	5293706;
UNII	WOA5J8TX6M;
Chemical and physical data
Formula	C38H47Br2N9O5
Molar mass	869.660 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)N[C@H](CC4=CC(=C(C(=C4)Br)O)Br)C(=O)N[C@@H](CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6;
	InChI InChI=1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)/t32-,33+/m0/s1; Key:ITIXDWVDFFXNEG-JHOUSYSJSA-N;

Short description: Chemical compound

Olcegepant (INN,^[1] code name BIBN-4096BS) is a calcitonin gene-related peptide receptor antagonist being studied as a potential treatment for migraines.^[2]

A 2013 meta-analysis found olcegepant and telcagepant were effective and safe compared to placebo.^[3]

References

↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 48". World Health Organization. pp. 256–7. https://www.who.int/medicines/publications/druginformation/innlists/RL48.pdf.
↑ "Possible site of action of CGRP antagonists in migraine". Cephalalgia 31 (6): 748–50. April 2011. doi:10.1177/0333102411398403. PMID 21383046.
↑ "Therapeutic effects and safety of olcegepant and telcagepant for migraine: A meta-analysis". Neural Regeneration Research 8 (10): 938–47. April 2013. doi:10.3969/j.issn.1673-5374.2013.10.009. PMID 25206386.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Olcegepant. Read more

[INN-1] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 48". World Health Organization. pp. 256–7. https://www.who.int/medicines/publications/druginformation/innlists/RL48.pdf.

[2] "Possible site of action of CGRP antagonists in migraine". Cephalalgia 31 (6): 748–50. April 2011. doi:10.1177/0333102411398403. PMID 21383046.

[3] "Therapeutic effects and safety of olcegepant and telcagepant for migraine: A meta-analysis". Neural Regeneration Research 8 (10): 938–47. April 2013. doi:10.3969/j.issn.1673-5374.2013.10.009. PMID 25206386.

[1]

[2]

[3]

Anonymous

Search

Chemistry:Olcegepant

Namespaces

More

Page actions

See also

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Clinical data

ATC code	None
Identifiers
IUPAC name N-[(1R)-2-[[(1S)-5-Amino-1-[[4-(pyridin-4-yl)piperazin-1-yl]carbonyl]pentyl]amino]-1-(3,5-dibromo-4-hydroxybenzyl)-2-oxoethyl]-4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide
CAS Number	204697-65-4
PubChem CID	6918509
ChemSpider	5293706
UNII	WOA5J8TX6M
Chemical and physical data
Formula	C₃₈H₄₇Br₂N₉O₅
Molar mass	869.660 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)N[C@H](CC4=CC(=C(C(=C4)Br)O)Br)C(=O)N[C@@H](CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
InChI InChI=1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)/t32-,33+/m0/s1 Key:ITIXDWVDFFXNEG-JHOUSYSJSA-N

Anonymous

Search

Chemistry:Olcegepant

See also

References

Navigation

Wiki tools

Page tools

Other projects

Categories