Biology:CRTC1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[5] and various regions of the adult central nervous system.[6]
Clinical significance
Production of CRTC1 is blocked in Alzheimer's disease.[7]
See also
References
- ↑ "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics 33 (2): 208–13. Feb 2003. doi:10.1038/ng1083. PMID 12539049. https://zenodo.org/record/1233401.
- ↑ "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. Aug 2003. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- ↑ "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. Oct 2003. doi:10.1073/pnas.1932773100. PMID 14506290.
- ↑ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23373.
- ↑ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers. http://atlasgeneticsoncology.org/Genes/CRTC1ID471ch19p13.html.
- ↑ "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4700–5. Mar 2007. doi:10.1073/pnas.0607524104. PMID 17360587. Bibcode: 2007PNAS..104.4700K.
- ↑ "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience 34 (17): 5776–87. Apr 2014. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838.
Further reading
- "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4700–5. Mar 2007. doi:10.1073/pnas.0607524104. PMID 17360587. Bibcode: 2007PNAS..104.4700K.
- "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal 274 (13): 3202–9. Jul 2007. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. Jun 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Experimental Cell Research 292 (1): 21–8. Jan 2004. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. Aug 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. http://faculty.washington.edu/scottjdw/pdfs/jin_curr_biol_2004_p1436.pdf.
- "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. Oct 2004. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Current Biology 14 (23): 2156–61. Dec 2004. doi:10.1016/j.cub.2004.11.002. PMID 15589160.
- "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes, Chromosomes & Cancer 43 (2): 202–5. Jun 2005. doi:10.1002/gcc.20168. PMID 15729701.
- "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation". Oncogene 25 (45): 6128–32. Oct 2006. doi:10.1038/sj.onc.1209627. PMID 16652146.
- "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology 80 (14): 7052–9. Jul 2006. doi:10.1128/JVI.00103-06. PMID 16809310.
- "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade". The FEBS Journal 273 (12): 2730–48. Jun 2006. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901.
- "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research 12 (13): 3902–7. Jul 2006. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685.
External links
- CRTC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CRTC1 genome location and CRTC1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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