Biology:Urate-ribonucleotide phosphorylase

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Short description: Enzyme in purine metabolism
urate-ribonucleotide phosphorylase
Identifiers
EC number2.4.2.16
CAS number9030-29-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an urate-ribonucleotide phosphorylase (EC 2.4.2.16) is an enzyme that catalyzes the chemical reaction

urate D-ribonucleotide + phosphate [math]\displaystyle{ \rightleftharpoons }[/math] urate + alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are urate D-ribonucleotide and phosphate, whereas its two products are urate and alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is urate-ribonucleotide:phosphate alpha-D-ribosyltransferase. Other names in common use include UAR phosphorylase, and urate-ribonucleotide:phosphate D-ribosyltransferase. This enzyme participates in purine metabolism.

References

  • "An intestinal phosphorylase for uric acid ribonucleoside". The Journal of Biological Chemistry 238: 3348–57. October 1963. PMID 14085385.