Biology:S-methyl-5'-thioinosine phosphorylase
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Short description: Class of enzymes
| S-methyl-5'-thioinosine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.2.44 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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S-methyl-5'-thioinosine phosphorylase (EC 2.4.2.44, MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase.[1] This enzyme catalyses the following chemical reaction
- S-methyl-5'-thioinosine + phosphate [math]\displaystyle{ \rightleftharpoons }[/math] hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
The catabolism of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine.
References
- ↑ "Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing". Biochemistry 50 (7): 1247–54. February 2011. doi:10.1021/bi101642d. PMID 21197954.
External links
- S-methyl-5'-thioinosine+phosphorylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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