Biology:N-acetyllactosamine synthase
| N-acetyllactosamine synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.4.1.90 | ||||||||
| CAS number | 9054-94-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N-acetyllactosamine synthase is a galactosyltransferase enzyme.[1][2][3][4][5][6] It is a component of lactose synthase[citation needed] This enzyme modifies the connection between two molecule UDP-galactose and N-actyl-D-glucosamine and generates two different molecules UDP and N-acetyllactosamine as products.[7] The main function of the enzyme is associated with the biosynthesis of glycoproteins and glycolipids in both human and animals.[7] In human, the activity of this enzyme can be found in Golgi apparatus.[7]
It is classified under EC 2.4.1.90.
The lack of this enzyme leads to glycolysation[7][8][9] which is a serious neurological disease. The nature of the disease causes fluid in the brain, abnormal inflammatory response and abnormal bleeding issues.[7][8][9]
See also
References
- ↑ "Isolation and characterization of an enriched Golgi fraction from rat brain". Biochimica et Biophysica Acta (BBA) - General Subjects 542 (2): 284–95. August 1978. doi:10.1016/0304-4165(78)90024-7. PMID 99178.
- ↑ "Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase". Biochimica et Biophysica Acta (BBA) - Enzymology 293 (1): 94–104. January 1973. doi:10.1016/0005-2744(73)90379-3. PMID 4631039.
- ↑ "Lactose synthetase". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology and Related Areas of Molecular Biology. 43. 1975. pp. 411–90. doi:10.1002/9780470122884.ch5. ISBN 9780470122884.
- ↑ "Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol". The Journal of Biological Chemistry 259 (9): 5797–802. May 1984. doi:10.1016/S0021-9258(18)91084-7. PMID 6201486.
- ↑ "Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction". The Journal of Biological Chemistry 245 (5): 1090–100. March 1970. doi:10.1016/S0021-9258(18)63293-4. PMID 4392041.
- ↑ Taniguchi, Naoyuki; Honke, Koichi; Fukuda, Minoru (2002). Handbook of glycosyltransferases and related genes (1st ed.). Springer. ISBN 443170311X. https://books.google.com/books?id=iPgWjOyToIoC&q=review+N-acetyllactosamine+synthase&pg=PR5.
- ↑ 7.0 7.1 7.2 7.3 7.4 Springer Handbook of Enzymes. 27. 2006. doi:10.1007/3-540-30439-8. ISBN 978-3-540-26583-2.
- ↑ 8.0 8.1 "Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId". The Journal of Clinical Investigation 109 (6): 725–33. March 2002. doi:10.1172/jci0214010. PMID 11901181.
- ↑ 9.0 9.1 "Glycosylation in health and disease". Nature Reviews. Nephrology 15 (6): 346–366. June 2019. doi:10.1038/s41581-019-0129-4. PMID 30858582.
External links
- N-acetyllactosamine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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