Biology:Mannosyl-3-phosphoglycerate synthase

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Short description: Class of enzymes
mannosyl-3-phosphoglycerate synthase
Identifiers
EC number2.4.1.217
CAS number393512-63-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) is an enzyme that catalyzes the chemical reaction

GDP-mannose + 3-phospho-D-glycerate [math]\displaystyle{ \rightleftharpoons }[/math] GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thus, the two substrates of this enzyme are GDP-mannose and 3-phospho-D-glycerate, whereas its two products are GDP and 2-(alpha-D-mannosyl)-3-phosphoglycerate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase. This enzyme is also called MPG synthase.

References

  • "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes". J. Biol. Chem. 276 (47): 43580–8. 2001. doi:10.1074/jbc.M108054200. PMID 11562374.