Biology:Matriptase
From HandWiki
| Peptidase S1A, matripase | |
|---|---|
| Identifiers | |
| Symbol | S1A |
| InterPro | IPR017051 |
| Membranome | 1287 |
Matriptases (EC 3.4.21.109) are an enzyme family.[1][2] This enzyme cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. It belongs to proteases of PA superfamily.
Human matriptases
References
- ↑ "Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease". The Journal of Biological Chemistry 275 (47): 36720–5. November 2000. doi:10.1074/jbc.M007802200. PMID 10962009.
- ↑ "Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity". The Journal of Biological Chemistry 274 (26): 18231–6. June 1999. doi:10.1074/jbc.274.26.18231. PMID 10373424.
External links
- Matriptase at the US National Library of Medicine Medical Subject Headings (MeSH)
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